U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SHM2 serine hydroxymethyltransferase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832736, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SHM2
    Official Full Name
    serine hydroxymethyltransferase 2
    Primary source
    TAIR:AT5G26780
    Locus tag
    AT5G26780
    See related
    Araport:AT5G26780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2P16.40; F2P16_40; serine hydroxymethyltransferase 2; SERINE HYDROXYMETHYLTRANSFERASE 2
    Summary
    Encodes a protein with serine hydroxymethyltransferase activity which is thought to be localized in the mitochondrial matrix. SHM2 expression fails to rescue the conditional lethal phenotype of the shm1-1 mutant, defective in SHM1.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SHM2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (9418137..9422228)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene myosin heavy chain, cardiac protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene xaa-pro aminopeptidase P

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The presequence of Arabidopsis serine hydroxymethyltransferase SHM2 selectively prevents import into mesophyll mitochondria. Engel N, et al. Plant Physiol, 2011 Dec. PMID 21976482, Free PMC Article
    2. Folate polyglutamylation eliminates dependence of activity on enzyme concentration in mitochondrial serine hydroxymethyltransferases from Arabidopsis thaliana. Wei Z, et al. Arch Biochem Biophys, 2013 Aug 1. PMID 23800877
    3. Internal architecture of mitochondrial complex I from Arabidopsis thaliana. Klodmann J, et al. Plant Cell, 2010 Mar. PMID 20197505, Free PMC Article
    4. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article
    5. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SHM2 is a functional mitochondrial Serine hydroxymethyltransferases. In leaves, the presequence of SHM2 selectively hinders targeting of the enzyme into mesophyll mitochondria.
      Title: The presequence of Arabidopsis serine hydroxymethyltransferase SHM2 selectively prevents import into mesophyll mitochondria.
    2. Structural modeling of SHM1, SHM2, and SHM4 presented features that may explain the activity differences between the mitochondrial and cytosolic isozymes.
      Title: Folate polyglutamylation eliminates dependence of activity on enzyme concentration in mitochondrial serine hydroxymethyltransferases from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_122560.2
    NM_180749.4
    NM_180750.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cobalt ion binding HDA PubMed 
    enables glycine hydroxymethyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in L-serine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plastid HDA PubMed 
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine hydroxymethyltransferase 2
    NP_568488.2
    • serine hydroxymethyltransferase 2 (SHM2); FUNCTIONS IN: glycine hydroxymethyltransferase activity, cobalt ion binding, zinc ion binding; INVOLVED IN: glycine metabolic process, L-serine metabolic process; LOCATED IN: mitochondrion, mitochondrial respiratory chain complex I; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Serine hydroxymethyltransferase, pyridoxal phosphate binding site (InterPro:IPR019798), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Serine hydroxymethyltransferase (InterPro:IPR001085); BEST Arabidopsis thaliana protein match is: serine transhydroxymethyltransferase 1 (TAIR:AT4G37930.1); Has 11562 Blast hits to 11539 proteins in 2821 species: Archae - 258; Bacteria - 6362; Metazoa - 333; Fungi - 287; Plants - 321; Viruses - 6; Other Eukaryotes - 3995 (source: NCBI BLink).
    NP_851080.1
    • serine hydroxymethyltransferase 2 (SHM2); FUNCTIONS IN: glycine hydroxymethyltransferase activity, cobalt ion binding, zinc ion binding; INVOLVED IN: glycine metabolic process, L-serine metabolic process; LOCATED IN: mitochondrion, mitochondrial respiratory chain complex I; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Serine hydroxymethyltransferase, pyridoxal phosphate binding site (InterPro:IPR019798), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Serine hydroxymethyltransferase (InterPro:IPR001085); BEST Arabidopsis thaliana protein match is: serine transhydroxymethyltransferase 1 (TAIR:AT4G37930.1); Has 11653 Blast hits to 11631 proteins in 2851 species: Archae - 258; Bacteria - 6455; Metazoa - 332; Fungi - 287; Plants - 321; Viruses - 6; Other Eukaryotes - 3994 (source: NCBI BLink).
    NP_851081.1
    • serine hydroxymethyltransferase 2 (SHM2); FUNCTIONS IN: glycine hydroxymethyltransferase activity, cobalt ion binding, zinc ion binding; INVOLVED IN: glycine metabolic process, L-serine metabolic process; LOCATED IN: mitochondrion, mitochondrial respiratory chain complex I; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Serine hydroxymethyltransferase, pyridoxal phosphate binding site (InterPro:IPR019798), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Serine hydroxymethyltransferase (InterPro:IPR001085); BEST Arabidopsis thaliana protein match is: serine transhydroxymethyltransferase 1 (TAIR:AT4G37930.1); Has 11607 Blast hits to 11584 proteins in 2835 species: Archae - 259; Bacteria - 6404; Metazoa - 333; Fungi - 289; Plants - 321; Viruses - 6; Other Eukaryotes - 3995 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9418137..9422228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343982.1 → NP_001331385.1  serine hydroxymethyltransferase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z258, Q8GRI1, Q94C74
      UniProtKB/TrEMBL
      A0A178UER6, A0A5S9Y7G7
      Conserved Domains (1) summary
      PLN03226
      Location:41 → 517
      PLN03226; serine hydroxymethyltransferase; Provisional

    2. NM_180749.4 → NP_851080.1  serine hydroxymethyltransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851080.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z258, Q8GRI1, Q94C74
      UniProtKB/TrEMBL
      A0A178UER6, A0A5S9Y7G7
      Conserved Domains (1) summary
      PLN03226
      Location:41 → 517
      PLN03226; serine hydroxymethyltransferase; Provisional

    3. NM_180750.2 → NP_851081.1  serine hydroxymethyltransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851081.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y7G7
      Conserved Domains (2) summary
      PLN03226
      Location:41 → 533
      PLN03226; serine hydroxymethyltransferase; Provisional
      pfam00464
      Location:55 → 468
      SHMT; Serine hydroxymethyltransferase

    4. NM_122560.2 → NP_568488.2  serine hydroxymethyltransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568488.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y7G7
      Conserved Domains (2) summary
      PLN03226
      Location:41 → 533
      PLN03226; serine hydroxymethyltransferase; Provisional
      pfam00464
      Location:55 → 468
      SHMT; Serine hydroxymethyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94C74.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.