BSK1 BR-signaling kinase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BSK1
Official Full Name: BR-signaling kinase 1
Primary source: TAIR:AT4G35230
Locus tag: AT4G35230
See related: Araport:AT4G35230
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BR-signaling kinase 1; brassinosteroid-signaling kinase 1; F23E12.210; F23E12_210
Summary: Encodes BR-signaling kinase 1 (BSK1), one of the three homologous BR-signaling kinases (BSK1, AT4G35230; BSK2, AT5G46570; BSK3, AT4G00710). Mediates signal transduction from receptor kinase BRI1 by functioning as the substrate of BRI1. Plasma membrane localized.
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Genomic context

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See BSK1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (16755092..16758358, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRASSINOSTEROID-SIGNALING KINASE 1 modulates OPEN STOMATA 1 phosphorylation and contributes to stomatal closure and plant immunity.
Title: BRASSINOSTEROID-SIGNALING KINASE 1 modulates OPEN STOMATA 1 phosphorylation and contributes to stomatal closure and plant immunity.
BRASSINOSTEROID-SIGNALING KINASE1 associates with and is required for cysteine protease RESPONSE TO DEHYDRATION 19-mediated disease resistance in Arabidopsis.
Title: BRASSINOSTEROID-SIGNALING KINASE1 associates with and is required for cysteine protease RESPONSE TO DEHYDRATION 19-mediated disease resistance in Arabidopsis.
Arabidopsis protein S-acyl transferases positively mediate BR signaling through S-acylation of BSK1.
Title: Arabidopsis protein S-acyl transferases positively mediate BR signaling through S-acylation of BSK1.
Results indicate that brassinosteroid-signaling kinase 1 (BSK1) regulates plant immunity by phosphorylating MAPK Kinase Kinase 5 (MAPKKK5).
Title: BRASSINOSTEROID-SIGNALING KINASE1 Phosphorylates MAPKKK5 to Regulate Immunity in Arabidopsis.
The ability of the kinase domain of BRI1 to generate cGMP depends on its kinase catalytic ability. Furthermore, cGMP stimulates phosphorylation of BSK1. Therefore, cGMP is proposed to act as a modulator to stimulate activation of downstream phosphorylation of members of the BRI1 signaling pathway.
Title: The brassinosteroid receptor BRI1 can generate cGMP enabling cGMP-dependent downstream signaling.
Disruption of BSK1 membrane localization affects the BSK1-FLS2 interactions, suggesting the membrane association of BSK1 is important for both edr2-mediated signaling.
Title: BSK1, a receptor-like cytoplasmic kinase, involved in both BR signaling and innate immunity in Arabidopsis.
BSK1 is a positive regulator of defense responses and has a significant role in pathogen-associated molecular pattern-trigged immunity.
Title: BR-SIGNALING KINASE1 physically associates with FLAGELLIN SENSING2 and regulates plant innate immunity in Arabidopsis.
is involved in brassinosteroid signal transduction
Title: Dramatic change in function and expression pattern of a gene duplicated by polyploidy created a paternal effect gene in the Brassicaceae.
3 homologous brassinosteroid (BR)-signaling kinases(BSK1 encoded by At4g35230, BSK2, BSK3)were identified; the BSKs are phosphorylated by BRI1; results demonstrate that BSKs are the substrates of BRI1 kinase that activate downstream BR signal transduction
Title: BSKs mediate signal transduction from the receptor kinase BRI1 in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_119689.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brassinosteroid mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: BR-signaling kinase 1

NP_567980.1

BR-signaling kinase 1 (BSK1); FUNCTIONS IN: binding, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: brassinosteroid mediated signaling pathway, N-terminal protein myristoylation; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Protein kinase, catalytic domain (InterPro:IPR000719), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase protein with tetratricopeptide repeat domain (TAIR:AT5G59010.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16755092..16758358 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119689.4 → NP_567980.1 BR-signaling kinase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567980.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65504, Q944A7

UniProtKB/TrEMBL

A0A178V289, A0A5S9Y108, A0A654FW65

Conserved Domains (2) summary

sd00006
Location:407 → 431

TPR; TPR repeat [structural motif]

cl21453
Location:90 → 330

PKc_like; Protein Kinases, catalytic domain