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    PSKR1 phytosulfokin receptor 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814753, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PSKR1
    Official Full Name
    phytosulfokin receptor 1
    Primary source
    TAIR:AT2G02220
    Locus tag
    AT2G02220
    See related
    Araport:AT2G02220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPSKR1; PHYTOSULFOKIN RECEPTOR; phytosulfokin receptor 1; PHYTOSULFOKIN RECEPTOR 1; PSK RECEPTOR 1
    Summary
    Encodes a protein interacting with phytosulfokine, a five amino acid sulfated peptide (YIYTQ). Contains dual guanylate cyclase and kinase catalytic activities that operate in vivo.
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    Genomic context

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    See PSKR1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (583797..587401, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene phloem protein 2-B1 Neighboring gene F-box family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Controlling the Heterodimerisation of the Phytosulfokine Receptor 1 (PSKR1) via Island Loop Modulation. de Souza JV, et al. Int J Mol Sci, 2021 Feb 11. PMID 33670396, Free PMC Article
    2. The phytosulfokine (PSK) receptor is capable of guanylate cyclase activity and enabling cyclic GMP-dependent signaling in plants. Kwezi L, et al. J Biol Chem, 2011 Jun 24. PMID 21504901, Free PMC Article
    3. Phytosulfokine-α controls hypocotyl length and cell expansion in Arabidopsis thaliana through phytosulfokine receptor 1. Stührwohldt N, et al. PLoS One, 2011. PMID 21698171, Free PMC Article
    4. Phytosulfokine control of growth occurs in the epidermis, is likely to be non-cell autonomous and is dependent on brassinosteroids. Hartmann J, et al. Plant J, 2013 Feb. PMID 23083315
    5. Kinase activity and calmodulin binding are essential for growth signaling by the phytosulfokine receptor PSKR1. Hartmann J, et al. Plant J, 2014 Apr. PMID 24495073

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Controlling the Heterodimerisation of the Phytosulfokine Receptor 1 (PSKR1) via Island Loop Modulation.
      Title: Controlling the Heterodimerisation of the Phytosulfokine Receptor 1 (PSKR1) via Island Loop Modulation.
    2. Peptide signaling of growth by PSKR1 is regulated by differential phosphorylation of the juxtamembrane and C-terminal domains of the intracellular receptor part and suggest that interaction of PSKR1 with calmodulin serves a function other than the regulation of kinase activity.
      Title: Phosphorylation of the phytosulfokine peptide receptor PSKR1 controls receptor activity.
    3. Phytosulfokine signalling through PSKR1 stimulates the Hyaloperonospora arabidopsidis infection cycle.
      Title: Evolutionarily distant pathogens require the Arabidopsis phytosulfokine signalling pathway to establish disease.
    4. Size exclusion and analytical ultracentrifugation analysis of the PSKR1cd suggest that it is reversibly dimeric in solution, which was further confirmed by biflourescence complementation. Taken together, these data suggest that in this novel type of receptor domain architecture, specific phosphorylation and dimerization are possibly essential mechanisms for ligand-mediated catalysis and signaling
      Title: Phosphorylation of the dimeric cytoplasmic domain of the phytosulfokine receptor, PSKR1.
    5. Conserved phosphorylation sites in the activation loop of the Arabidopsis phytosulfokine receptor PSKR1 differentially affect kinase and receptor activity.
      Title: Conserved phosphorylation sites in the activation loop of the Arabidopsis phytosulfokine receptor PSKR1 differentially affect kinase and receptor activity.
    6. Calcium is the switch in the moonlighting dual function of PSKR1
      Title: Calcium is the switch in the moonlighting dual function of the ligand-activated receptor kinase phytosulfokine receptor 1.
    7. data reveal the structural basis for PSKR recognition of PSK and allosteric activation of PSKR by PSK, opening up new avenues for the design of PSKR-specific small molecules
      Title: Allosteric receptor activation by the plant peptide hormone phytosulfokine.
    8. PSK signaling requires Ca(2+) /CaM binding and kinase activity of PSKR1 in planta.
      Title: Kinase activity and calmodulin binding are essential for growth signaling by the phytosulfokine receptor PSKR1.
    9. PSK signaling mediated by PSKR1 attenuates pattern-triggered immunity but stimulates growth.
      Title: The peptide growth factor, phytosulfokine, attenuates pattern-triggered immunity.
    10. the tyrosine sulfated peptide receptors PSKR1 and PSY1R are not only involved in growth and development but also in plant defense.
      Title: PSKR1 and PSY1R-mediated regulation of plant defense responses.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_126282.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables guanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of defense response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    phytosulfokin receptor 1
    NP_178330.1
    • phytosulfokin receptor 1 (PSKR1); FUNCTIONS IN: peptide receptor activity, protein serine/threonine kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, response to wounding; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat, typical subtype (InterPro:IPR003591), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: phytosylfokine-alpha receptor 2 (TAIR:AT5G53890.1); Has 188205 Blast hits to 128830 proteins in 4018 species: Archae - 120; Bacteria - 18455; Metazoa - 56562; Fungi - 9680; Plants - 79633; Viruses - 405; Other Eukaryotes - 23350 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      583797..587401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126282.3 → NP_178330.1  phytosulfokin receptor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178330.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNS6, Q8S8L2, Q9ZVR7
      UniProtKB/TrEMBL
      A0A178VSQ4, A0A5S9WWI1, C0LGJ8
      Conserved Domains (2) summary
      PLN00113
      Location:11 → 1008
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:318 → 341
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZVR7.4

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