U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FBW2 F-BOX WITH WD-40 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826476, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FBW2
    Official Full Name
    F-BOX WITH WD-40 2
    Primary source
    TAIR:AT4G08980
    Locus tag
    AT4G08980
    See related
    Araport:AT4G08980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F-BOX WITH WD-40 2; T3H13.1; T3H13_1
    Summary
    Encodes an F-box gene that is a novel negative regulator of AGO1 protein levels and may play a role in ABA signalling and/or response.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FBW2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (5758014..5760569)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene phosphotyrosyl phosphatase activator (PTPA) family protein Neighboring gene pseudo Neighboring gene DNA (cytosine-5-)-methyltransferase family protein Neighboring gene miscRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An endogenous F-box protein regulates ARGONAUTE1 in Arabidopsis thaliana. Earley K, et al. Silence, 2010 Jul 12. PMID 20624295, Free PMC Article
    2. The Arabidopsis F-box protein FBW2 targets AGO1 for degradation to prevent spurious loading of illegitimate small RNA. Hacquard T, et al. Cell Rep, 2022 Apr 12. PMID 35417704, Free PMC Article
    3. AtSKIP18 and AtSKIP31, F-box subunits of the SCF E3 ubiquitin ligase complex, mediate the degradation of 14-3-3 proteins in Arabidopsis. Hong JP, et al. Biochem Biophys Res Commun, 2017 Mar 25. PMID 28189687
    4. F-box proteins in Arabidopsis. Xiao W, et al. Trends Plant Sci, 2000 Nov. PMID 11077244
    5. Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis. Risseeuw EP, et al. Plant J, 2003 Jun. PMID 12795696

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis F-box protein FBW2 targets AGO1 for degradation to prevent spurious loading of illegitimate small RNA.
      Title: The Arabidopsis F-box protein FBW2 targets AGO1 for degradation to prevent spurious loading of illegitimate small RNA.
    2. AtSKIP18 and AtSKIP31, were shown to mediate the degradation of Arabidopsis 14-3-3s. Mutational analyses of AtSKIP18 and AtSKIP31 indicated that the phosphorylation of AtSKIPs is critical for interaction and degradation of 14-3-3s. The loss-of-function mutation in AtSKIP31 resulted in enhanced primary root growth under nitrogen deficient conditions. [AtSKIP18]
      Title: AtSKIP18 and AtSKIP31, F-box subunits of the SCF E3 ubiquitin ligase complex, mediate the degradation of 14-3-3 proteins in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001084890.3
    NM_001160743.1
    NM_116967.3
    NM_179015.3
    NM_202794.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-transcriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    F-BOX WITH WD-40 2
    NP_001078359.1
    • F-BOX WITH WD-40 2 (FBW2); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process, posttranscriptional regulation of gene expression; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: RNI-like superfamily protein (TAIR:AT4G05460.1); Has 1165 Blast hits to 1048 proteins in 88 species: Archae - 0; Bacteria - 0; Metazoa - 539; Fungi - 16; Plants - 571; Viruses - 0; Other Eukaryotes - 39 (source: NCBI BLink).
    NP_001154215.1
    • F-BOX WITH WD-40 2 (FBW2); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process, posttranscriptional regulation of gene expression; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: RNI-like superfamily protein (TAIR:AT4G05460.1); Has 1165 Blast hits to 1048 proteins in 88 species: Archae - 0; Bacteria - 0; Metazoa - 539; Fungi - 16; Plants - 571; Viruses - 0; Other Eukaryotes - 39 (source: NCBI BLink).
    NP_567343.1
    • F-BOX WITH WD-40 2 (FBW2); BEST Arabidopsis thaliana protein match is: RNI-like superfamily protein (TAIR:AT4G05460.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_849346.1
    • F-BOX WITH WD-40 2 (FBW2); BEST Arabidopsis thaliana protein match is: RNI-like superfamily protein (TAIR:AT4G05460.1); Has 1165 Blast hits to 1048 proteins in 88 species: Archae - 0; Bacteria - 0; Metazoa - 539; Fungi - 16; Plants - 571; Viruses - 0; Other Eukaryotes - 39 (source: NCBI BLink).
    NP_974523.1
    • F-BOX WITH WD-40 2 (FBW2); BEST Arabidopsis thaliana protein match is: RNI-like superfamily protein (TAIR:AT4G05460.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      5758014..5760569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001084890.3 → NP_001078359.1  F-BOX WITH WD-40 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078359.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGN7, Q9ZPE4
      UniProtKB/TrEMBL
      A0A178UUC5, A0A5S9XSE6, A0A7G2EWU8
      Conserved Domains (3) summary
      cd09293
      Location:63 → 244
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:51 → 83
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:10 → 55
      F-box-like

    2. NM_179015.3 → NP_849346.1  F-BOX WITH WD-40 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGN7, Q9ZPE4
      UniProtKB/TrEMBL
      A0A178UUC5, A0A5S9XSE6, A0A7G2EWU8
      Conserved Domains (3) summary
      cd09293
      Location:63 → 244
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:51 → 83
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:10 → 55
      F-box-like

    3. NM_116967.3 → NP_567343.1  F-BOX WITH WD-40 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567343.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGN7, Q9ZPE4
      UniProtKB/TrEMBL
      A0A178UUC5, A0A5S9XSE6, A0A7G2EWU8
      Conserved Domains (3) summary
      cd09293
      Location:63 → 244
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:51 → 83
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:10 → 55
      F-box-like

    4. NM_001160743.1 → NP_001154215.1  F-BOX WITH WD-40 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154215.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGN7, Q9ZPE4
      UniProtKB/TrEMBL
      A0A178UUC5, A0A5S9XSE6, A0A7G2EWU8
      Conserved Domains (3) summary
      cd09293
      Location:63 → 244
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:51 → 83
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:10 → 55
      F-box-like

    5. NM_202794.1 → NP_974523.1  F-BOX WITH WD-40 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974523.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGN7, Q9ZPE4
      UniProtKB/TrEMBL
      A0A178UUC5, A0A5S9XSE6, A0A7G2EWU8
      Conserved Domains (3) summary
      cd09293
      Location:63 → 244
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:51 → 83
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:10 → 55
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZPE4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools