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    GTG1 GPCR-type G protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842807, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GTG1
    Official Full Name
    GPCR-type G protein 1
    Primary source
    TAIR:AT1G64990
    Locus tag
    AT1G64990
    See related
    Araport:AT1G64990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F13O11.29; F13O11_29; GPCR-type G protein 1
    Summary
    Encodes a GPCR-type G protein receptor with nine predicted transmembrane domains. The protein binds abscisic acid (ABA) and is predicted to function as an ABA receptor. It has GTP-binding and GTPase activity and binds to ABA more effectively in the presence of GDP. GTG1 binds to GPA1, the alpha subunit of the heterotrimeric G protein. GPA1 (in its GTP-bound state) affects the GTP binding and GTPase activity of GTG1 and may act to down-regulate GTG1 binding to ABA. GTG1 is widely expressed throughout the plant and appears to be involved in the regulation of several ABA-dependent responses including seed germination, plant development, and promotion of stomatal closure. GTG1 transcript levels do not appear to change in response to ABA or abiotic stresses.
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    Genomic context

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    See GTG1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (24139851..24146281, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene gamma-tocopherol methyltransferase Neighboring gene Nucleotide-diphospho-sugar transferases superfamily protein Neighboring gene F-box only protein Neighboring gene WEB family protein (DUF827) Neighboring gene plasma protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Abscisic acid binds to recombinant Arabidopsis thaliana G-protein coupled receptor-type G-protein 1 in Sacaromycese cerevisiae and in vitro. Kharenko OA, et al. Plant Physiol Biochem, 2013 Jul. PMID 23624020
    2. G protein-coupled receptor-type G proteins are required for light-dependent seedling growth and fertility in Arabidopsis. Jaffé FW, et al. Plant Cell, 2012 Sep. PMID 23001037, Free PMC Article
    3. Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. Pandey S, et al. Cell, 2009 Jan 9. PMID 19135895
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results provide evidence of a binding-interaction between abscisic acid (ABA) and GTG1 in vitro and in vivo, in support of the previously proposed possibility of a biologically relevant interaction between GTG1 and ABA.
      Title: Abscisic acid binds to recombinant Arabidopsis thaliana G-protein coupled receptor-type G-protein 1 in Sacaromycese cerevisiae and in vitro.
    2. GTGs contribute to fertility, plant growth, and responses to light and sugars, but our molecular and genetic data using these mutants indicate that they respond normally in classic ABA responses.
      Title: G protein-coupled receptor-type G proteins are required for light-dependent seedling growth and fertility in Arabidopsis.
    3. Study identifies 2 proteins homologous to an orphan vertebrate GPCR (GPR89) and interact with the Arabidopsis G protein alpha subunit, GPA1, have intrinsic GTP-binding and GTPase activity; these proteins are named GTG1 (At1g64990) and GTG2.
      Title: Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036158.2
    NM_105173.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables abscisic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GPCR-type G protein 1
    NP_001031235.1
    • GPCR-type G protein 1 (GTG1); CONTAINS InterPro DOMAIN/s: GPCR 89-related (InterPro:IPR015672), Protein of unknown function DUF3735 (InterPro:IPR022535); BEST Arabidopsis thaliana protein match is: GPCR-type G protein 2 (TAIR:AT4G27630.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_176679.2
    • GPCR-type G protein 1 (GTG1); CONTAINS InterPro DOMAIN/s: GPCR 89-related (InterPro:IPR015672), Protein of unknown function DUF3735 (InterPro:IPR022535); BEST Arabidopsis thaliana protein match is: GPCR-type G protein 2 (TAIR:AT4G27630.2); Has 379 Blast hits to 368 proteins in 151 species: Archae - 4; Bacteria - 0; Metazoa - 175; Fungi - 67; Plants - 53; Viruses - 0; Other Eukaryotes - 80 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24139851..24146281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105173.4 → NP_176679.2  GPCR-type G protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176679.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G0WVT6, Q9XIP7
      UniProtKB/TrEMBL
      A0A5S9WS34, A0A654EWS4
      Conserved Domains (2) summary
      pfam12430
      Location:285 → 457
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:143 → 210
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

    2. NM_001036158.2 → NP_001031235.1  GPCR-type G protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031235.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G0WVT6, Q9XIP7
      UniProtKB/TrEMBL
      A0A5S9WS34, A0A654EWS4
      Conserved Domains (2) summary
      pfam12430
      Location:285 → 457
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:143 → 210
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XIP7.1

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