Ube4A Ubiquitination factor E4A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ube4Aprovided by FlyBase
Official Full Name: Ubiquitination factor E4Aprovided by FlyBase
Primary source: FLYBASE:FBgn0028467
Locus tag: Dmel_CG11070
See related: AllianceGenome:FB:FBgn0028467
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD34475; CG 11070; CG11070; Dmel\CG11070; E4 A; UBE4A; UFD2a
Summary: Predicted to enable ubiquitin-ubiquitin ligase activity. Involved in ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; embryonic esophagus; embryonic hypopharynx; embryonic/larval esophageal visceral muscle; and trunk visceral muscle primordium. Orthologous to human UBE4A (ubiquitination factor E4A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6658517..6662033)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6658517..6662033)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.
Title: UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ubiquitin-ubiquitin ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-ubiquitin ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-ubiquitin ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain