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    Klhl11 kelch-like 11 [ Mus musculus (house mouse) ]

    Gene ID: 217194, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhl11provided by MGI
    Official Full Name
    kelch-like 11provided by MGI
    Primary source
    MGI:MGI:2388648
    See related
    Ensembl:ENSMUSG00000048732 AllianceGenome:MGI:2388648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL11 (kelch like family member 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.3), cerebellum adult (RPKM 7.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl11 in Genome Data Viewer
    Location:
    11 D; 11 63.47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100347948..100363608, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100457122..100472782, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene FK506 binding protein 10 Neighboring gene 5'-nucleotidase, cytosolic IIIB Neighboring gene kelch-like 10 Neighboring gene STARR-positive B cell enhancer ABC_E3020 Neighboring gene microRNA 7116 Neighboring gene ATP citrate lyase Neighboring gene STARR-positive B cell enhancer ABC_E3021 Neighboring gene nuclear encoded tRNA serine 1 (anticodon GGA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Lenihan JA, et al. Mol Neurobiol, 2017 Dec. PMID 27889896
    2. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172565.2 → NP_766153.1  kelch-like protein 11 precursor

      See identical proteins and their annotated locations for NP_766153.1

      Status: VALIDATED

      Source sequence(s)
      AK029101
      Consensus CDS
      CCDS25424.1
      UniProtKB/Swiss-Prot
      Q3TDZ6, Q8CE33, Q91VP6
      UniProtKB/TrEMBL
      Q14DU1
      Related
      ENSMUSP00000054963.4, ENSMUST00000056665.4
      Conserved Domains (6) summary
      smart00612
      Location:612 → 658
      Kelch; Kelch domain
      smart00225
      Location:96 → 201
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00038
      Location:400 → 440
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:86 → 198
      BTB; BTB/POZ domain
      pfam01344
      Location:443 → 487
      Kelch_1; Kelch motif
      pfam07707
      Location:206 → 308
      BACK; BTB And C-terminal Kelch

    RNA

    1. NR_155072.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590968

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100347948..100363608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CE33.1 GenPept UniProtKB/Swiss-Prot:Q8CE33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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