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    Plcxd1 phosphatidylinositol-specific phospholipase C, X domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 403178, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plcxd1provided by MGI
    Official Full Name
    phosphatidylinositol-specific phospholipase C, X domain containing 1provided by MGI
    Primary source
    MGI:MGI:2685422
    See related
    Ensembl:ENSMUSG00000064247 AllianceGenome:MGI:2685422
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm576; A330045H12Rik
    Summary
    Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in cytoplasm. Orthologous to human PLCXD1 (phosphatidylinositol specific phospholipase C X domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 16.9), thymus adult (RPKM 16.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plcxd1 in Genome Data Viewer
    Location:
    5 F; 5 53.3 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110247661..110253819)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110099969..110105953)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6361 Neighboring gene STARR-seq mESC enhancer starr_13941 Neighboring gene STARR-positive B cell enhancer ABC_E2756 Neighboring gene STARR-seq mESC enhancer starr_13942 Neighboring gene predicted gene, 35315 Neighboring gene STARR-positive B cell enhancer ABC_E3596 Neighboring gene predicted gene, 54335 Neighboring gene STARR-positive B cell enhancer ABC_E4778 Neighboring gene STARR-positive B cell enhancer ABC_E10339 Neighboring gene STARR-positive B cell enhancer ABC_E3597 Neighboring gene GTP binding protein 6 (putative) Neighboring gene zinc finger protein 605 Neighboring gene nucleophosmin pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6362 Neighboring gene STARR-seq mESC enhancer starr_13946 Neighboring gene checkpoint with forkhead and ring finger domains Neighboring gene predicted gene 15787

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice. Goldsworthy M, et al. PLoS One, 2013. PMID 23826075, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphoric diester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PI-PLC X domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281812.2 → NP_001268741.1  PI-PLC X domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC166747
      Conserved Domains (1) summary
      cl14615
      Location:30 → 235
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    2. NM_001408688.1 → NP_001395617.1  PI-PLC X domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166747
      UniProtKB/Swiss-Prot
      Q8BYI5, Q8CHS4
      UniProtKB/TrEMBL
      D3Z2L0
      Related
      ENSMUSP00000119248.3, ENSMUST00000141066.9

    3. NM_001408689.1 → NP_001395618.1  PI-PLC X domain-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166747
      UniProtKB/Swiss-Prot
      Q8BYI5, Q8CHS4

    4. NM_001408690.1 → NP_001395619.1  PI-PLC X domain-containing protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC166747

    5. NM_001408691.1 → NP_001395620.1  PI-PLC X domain-containing protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC166747

    6. NM_001408692.1 → NP_001395621.1  PI-PLC X domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166747

    7. NM_207279.3 → NP_997162.2  PI-PLC X domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_997162.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC166747
      Consensus CDS
      CCDS39208.2
      UniProtKB/Swiss-Prot
      Q8BYI5, Q8CHS4
      UniProtKB/TrEMBL
      G3X9J3
      Related
      ENSMUSP00000083892.4, ENSMUST00000086687.10
      Conserved Domains (1) summary
      cd08616
      Location:61 → 351
      PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1

    RNA

    1. NR_176795.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166747
      Related
      ENSMUST00000125748.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110247661..110253819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249507.4 → XP_011247809.1  PI-PLC X domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011247809.1

      UniProtKB/Swiss-Prot
      Q8BYI5, Q8CHS4
      UniProtKB/TrEMBL
      D3Z2L0
      Conserved Domains (1) summary
      cd08616
      Location:11 → 301
      PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1

    2. XM_006535059.4 → XP_006535122.2  PI-PLC X domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8BYI5, Q8CHS4
      Conserved Domains (1) summary
      cd08616
      Location:30 → 320
      PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHS4.1 GenPept UniProtKB/Swiss-Prot:Q8CHS4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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