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    CG6805 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36911, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG6805provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034179
    Locus tag
    Dmel_CG6805
    See related
    AllianceGenome:FB:FBgn0034179
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK01299; CK01299; Dmel\CG6805; IPP
    Summary
    Predicted to enable inositol trisphosphate phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in neuron projection; plasma membrane; and ruffle. Is expressed in several structures, including adult head; cephalic furrow; head mesoderm; plasmatocyte primordium; and pole plasm. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to several human genes including INPP5K (inositol polyphosphate-5-phosphatase K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6805 in Genome Data Viewer
    Location:
    53E4-53E4; 2-81 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17005451..17007501)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12892956..12895006)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene prenyl protease type I Neighboring gene Asparaginyl-tRNA synthetase, mitochondrial Neighboring gene Nuclear inhibitor of Protein phosphatase 1 Neighboring gene Eps15 homology domain containing protein-binding protein 1 Neighboring gene Poly(A) binding protein interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. knot is required for the hypopharyngeal lobe and its derivatives in the Drosophila embryo. Seecoomar M, et al. Mech Dev, 2000 Mar 1. PMID 10704845
    2. B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster. Vrailas-Mortimer AD, et al. MicroPubl Biol, 2021 Jan 18. PMID 33474526, Free PMC Article
    3. Population genomics of Wolbachia and mtDNA in Drosophila simulans from California. Signor S. Sci Rep, 2017 Oct 17. PMID 29042606, Free PMC Article
    4. A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. Seeds AM, et al. J Biol Chem, 2004 Nov 5. PMID 15322119
    5. Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila. Coelho DS, et al. Cell Rep, 2013 Nov 14. PMID 24183663, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables inositol trisphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6805-PA
    CG6805-PB
    NP_001246379.1
    NP_611178.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17005451..17007501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137334.4 → NP_611178.1  uncharacterized protein Dmel_CG6805, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611178.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K161
      Related
      FBpp0086120
      Conserved Domains (1) summary
      cl00490
      Location:12 → 308
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. NM_001259450.2 → NP_001246379.1  uncharacterized protein Dmel_CG6805, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246379.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7D8
      Conserved Domains (1) summary
      cl00490
      Location:12 → 308
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7D8 A0A0B4K7D8
    Q7K161 Q7K161

    Gene LinkOut

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