Gmer GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gmerprovided by FlyBase
Official Full Name: GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductaseprovided by FlyBase
Primary source: FLYBASE:FBgn0267823
Locus tag: Dmel_CG3495
See related: AllianceGenome:FB:FBgn0267823
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3495; Dmel\CG3495; DmGMER; GER; gmer; l(2)SH1931
Summary: Enables GDP-L-fucose synthase activity. Involved in 'de novo' GDP-L-fucose biosynthetic process. Predicted to be located in cytosol. Is expressed in organism. Orthologous to human GFUS (GDP-L-fucose synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 59B4-59B4; 2-101 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22887574..22888857, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18775097..18776380, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cloning, purification and charactrization of Gmer
Title: Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GDP-L-fucose synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GDP-L-fucose synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables GDP-mannose 3,5-epimerase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleotide-sugar biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase

Names: CG3495-PA; GDP-keto-6-deoxymannose 3,5-epimerase/4-reductase; Gmer-PA; lethal (2) SH1931

NP_611734.1

EC 1.-.-.-

EC 1.1.1.271

EC 5.1.3.18

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

22887574..22888857 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_137890.3 → NP_611734.1 GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611734.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q1H8X1, Q8MS16, Q9W1X8

UniProtKB/TrEMBL

B6IDX2

Related

FBpp0071816

Conserved Domains (2) summary

cd05239
Location:3 → 313

GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

pfam01370
Location:4 → 234

Epimerase; NAD dependent epimerase/dehydratase family