Lmnb1 lamin B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lmnb1provided by MGI
Official Full Name: lamin B1provided by MGI
Primary source: MGI:MGI:96795
See related: Ensembl:ENSMUSG00000024590 AllianceGenome:MGI:96795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables phospholipase binding activity and sequence-specific double-stranded DNA binding activity. A structural constituent of nuclear lamina. Predicted to be involved in several processes, including cellular response to L-glutamate; nucleus organization; and protein localization to nuclear envelope. Located in nuclear inner membrane and nuclear lumen. Is active in nuclear lamina. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and musculoskeletal system. Used to study adult-onset autosomal dominant demyelinating leukodystrophy. Human ortholog(s) of this gene implicated in adult-onset autosomal dominant demyelinating leukodystrophy and primary autosomal recessive microcephaly. Orthologous to human LMNB1 (lamin B1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 89.9), thymus adult (RPKM 41.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 D3; 18 30.84 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (56840885..56886496)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (56707813..56753424)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Progesterone depletion results in Lamin B1 loss and induction of cell death in mouse trophoblast giant cells.
Title: Progesterone depletion results in Lamin B1 loss and induction of cell death in mouse trophoblast giant cells.
WTAP-mediated N6-methyladenosine modification promotes the inflammation, mitochondrial damage and ferroptosis of kidney tubular epithelial cells in acute kidney injury by regulating LMNB1 expression and activating NF-kappaB and JAK2/STAT3 pathways.
Title: WTAP-mediated N6-methyladenosine modification promotes the inflammation, mitochondrial damage and ferroptosis of kidney tubular epithelial cells in acute kidney injury by regulating LMNB1 expression and activating NF-κB and JAK2/STAT3 pathways.
Colocalization Analysis of Peripheral Myelin Protein-22 and Lamin-B1 in the Schwann Cell Nuclei of Wt and TrJ Mice.
Title: Colocalization Analysis of Peripheral Myelin Protein-22 and Lamin-B1 in the Schwann Cell Nuclei of Wt and TrJ Mice.
Increased expression of LAP2beta eliminates nuclear membrane ruptures in nuclear lamin-deficient neurons and fibroblasts.
Title: Increased expression of LAP2β eliminates nuclear membrane ruptures in nuclear lamin-deficient neurons and fibroblasts.
Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease.
Title: Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease.
Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis.
Title: Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis.
Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins.
Title: Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins.
Development and Optimization of a High-Content Analysis Platform to Identify Suppressors of Lamin B1 Overexpression as a Therapeutic Strategy for Autosomal Dominant Leukodystrophy.
Title: Development and Optimization of a High-Content Analysis Platform to Identify Suppressors of Lamin B1 Overexpression as a Therapeutic Strategy for Autosomal Dominant Leukodystrophy.
Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity.
Title: Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity.
ROS/p38MAPK-induced lamin B1 accumulation promotes chronic kidney disease-associated vascular smooth muscle cells senescence.
Title: ROS/p38MAPK-induced lamin B1 accumulation promotes chronic kidney disease-associated vascular smooth muscle cells senescence.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lamb1-1 (e-PCR), detects polymorphism
- UniSTS:143751

Lmnb1 (e-PCR), detects polymorphism
- UniSTS:463523

Lmnb1 (e-PCR), detects polymorphism
- UniSTS:143782

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables JUN kinase binding	NAS Non-traceable Author Statement more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear lamina	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to L-glutamate	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	ISO Inferred from Sequence Orthology more info
involved_in nuclear envelope organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear pore localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of JNK cascade	NAS Non-traceable Author Statement more info	PubMed
involved_in protein localization to nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in lamin filament	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	TAS Traceable Author Statement more info
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear lamina	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear lamina	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear lamina	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lamin-B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.