Gtpbp3 GTP binding protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gtpbp3provided by RGD
Official Full Name: GTP binding protein 3provided by RGD
Primary source: RGD:1305367
See related: EnsemblRapid:ENSRNOG00000023403 AllianceGenome:RGD:1305367
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Predicted to be located in nucleus. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 23. Orthologous to human GTPBP3 (GTP binding protein 3, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 60.9), Kidney (RPKM 44.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18209747..18214838)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18175766..18180857)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (19897135..19902226)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131780 (e-PCR)
- UniSTS:215063

UniSTS:235923 (e-PCR)
- UniSTS:235923

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA wobble uridine modification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tRNA modification GTPase GTPBP3, mitochondrial

Names: GTP binding protein 3 (mitochondrial)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011919.1 → NP_001011919.1 tRNA modification GTPase GTPBP3, mitochondrial precursor

See identical proteins and their annotated locations for NP_001011919.1

Status: PROVISIONAL

Source sequence(s)

BC087083

UniProtKB/Swiss-Prot

Q5PQQ1

Related

ENSRNOP00000102399.1, ENSRNOT00000160174.1

Conserved Domains (3) summary

cd04164
Location:247 → 416

trmE; trmE is a tRNA modification GTPase

PRK05291
Location:35 → 492

trmE; tRNA modification GTPase TrmE; Reviewed

pfam10396
Location:35 → 152

TrmE_N; GTP-binding protein TrmE N-terminus