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    U2af2 U2 small nuclear RNA auxiliary factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308335, updated on 27-Nov-2024

    Summary

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    Official Symbol
    U2af2provided by RGD
    Official Full Name
    U2 small nuclear RNA auxiliary factor 2provided by RGD
    Primary source
    RGD:1310690
    See related
    EnsemblRapid:ENSRNOG00000015914 AllianceGenome:RGD:1310690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including C2H2 zinc finger domain binding activity; RNA binding activity; and enzyme binding activity. Predicted to be involved in negative regulation of protein ubiquitination; regulation of RNA splicing; and spliceosomal complex assembly. Predicted to be located in nucleus. Predicted to be part of Prp19 complex; U2-type spliceosomal complex; and U2AF complex. Predicted to be active in nuclear speck. Human ortholog(s) of this gene implicated in developmental delay, dysmorphic facies, and brain anomalies. Orthologous to human U2AF2 (U2 small nuclear RNA auxiliary factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 409.1), Spleen (RPKM 321.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See U2af2 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (77789752..77807307, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (68760911..68779730, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72312260..72329828, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ret finger protein-like 4A Neighboring gene Epsin 1 Neighboring gene coiled-coil domain containing 106 Neighboring gene zinc finger protein 581-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution. Zamore PD, et al. EMBO J, 1991 Jan. PMID 1824937, Free PMC Article
    2. Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor. Zamore PD, et al. Proc Natl Acad Sci U S A, 1989 Dec. PMID 2531895, Free PMC Article
    3. The splicing factor U2AF65 stabilizes TRF1 protein by inhibiting its ubiquitin-dependent proteolysis. Kim J, et al. Biochem Biophys Res Commun, 2014 Jan 17. PMID 24389012
    4. WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes. Davies RC, et al. Genes Dev, 1998 Oct 15. PMID 9784496, Free PMC Article
    5. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Webby CJ, et al. Science, 2009 Jul 3. PMID 19574390

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular function inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly-pyrimidine tract binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA 3'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA 3'-splice site binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2AF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2AF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of commitment complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor U2AF 65 kDa subunit
    Names
    U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427197.1 → NP_001414126.1  splicing factor U2AF 65 kDa subunit isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KNR7

    2. NM_001427198.1 → NP_001414127.1  splicing factor U2AF 65 kDa subunit isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000021392.7, ENSRNOT00000021391.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      77789752..77807307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589964.3 → XP_017445453.1  splicing factor U2AF 65 kDa subunit isoform X2

      UniProtKB/TrEMBL
      A0A8I6A9Y1
      Conserved Domains (1) summary
      TIGR01642
      Location:4 → 455
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    2. XM_017589963.3 → XP_017445452.1  splicing factor U2AF 65 kDa subunit isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9Y1
      Conserved Domains (1) summary
      TIGR01642
      Location:4 → 459
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    3. XM_063288682.1 → XP_063144752.1  splicing factor U2AF 65 kDa subunit isoform X3

    4. XM_039100506.2 → XP_038956434.1  splicing factor U2AF 65 kDa subunit isoform X4

      Conserved Domains (1) summary
      TIGR01642
      Location:1 → 310
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    Nucleotide Protein Strain
    Heading Accession and Version

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