Fkbp5 FKBP prolyl isomerase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fkbp5provided by RGD
Official Full Name: FKBP prolyl isomerase 5provided by RGD
Primary source: RGD:1309155
See related: EnsemblRapid:ENSRNOG00000022523 AllianceGenome:RGD:1309155
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heat shock protein binding activity; peptidyl-prolyl cis-trans isomerase activity; and protein-macromolecule adaptor activity. Involved in response to alcohol and response to cocaine. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Biomarker of alcohol dependence and cocaine abuse. Human ortholog(s) of this gene implicated in alcohol dependence; heroin dependence; and major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 109.1), Spleen (RPKM 80.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (6458931..6577227, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (6457207..6575404, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (7976704..8097290, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chronic adolescent stress alters GR-FKBP5 interactions in the hippocampus of adult female rats.
Title: Chronic adolescent stress alters GR-FKBP5 interactions in the hippocampus of adult female rats.
Dissecting the Long-Term Effect of Stress Early in Life on FKBP5: The Role of miR-20b-5p and miR-29c-3p.
Title: Dissecting the Long-Term Effect of Stress Early in Life on FKBP5: The Role of miR-20b-5p and miR-29c-3p.
Regulatory Effects of Maternal Immune Activation and Environmental Enrichment on Glucocorticoid Receptor and FKBP5 Expression in Stress-sensitive Regions of the Offspring Brain.
Title: Regulatory Effects of Maternal Immune Activation and Environmental Enrichment on Glucocorticoid Receptor and FKBP5 Expression in Stress-sensitive Regions of the Offspring Brain.
Duration of Reduction in Enduring Stress-Induced Hyperalgesia Via FKBP51 Inhibition Depends on Timing of Administration Relative to Traumatic Stress Exposure.
Title: Duration of Reduction in Enduring Stress-Induced Hyperalgesia Via FKBP51 Inhibition Depends on Timing of Administration Relative to Traumatic Stress Exposure.
Both maternal care received and fkbp5 variant influence stress-related phenotype in female rats.
Title: Both maternal care received and genotype influence stress-related phenotype in female rats.
Toy rotation influenced FK506 binding protein 5 mRNA expression, which is believed to be a regulator of the hypothalamic-pituitary-adrenal (HPA)-axis system, in the hippocampus and amygdala in a model of post-traumatic stress disorder.
Title: Differential effects of voluntary wheel running and toy rotation on the mRNA expression of neurotrophic factors and FKBP5 in a post-traumatic stress disorder rat model with the shuttle-box task.
The present findings suggest that Fkbp5 expression in mesocorticolimbic dopaminergic regions associates with early life stress-mediated sensitivity to alcohol drinking and that FKBP5 genotype interacts with parent-child relationship to influence alcohol drinking.
Title: Evidence for a Link Between Fkbp5/FKBP5, Early Life Social Relations and Alcohol Drinking in Young Adult Rats and Humans.
FKBP5/GR and miR124a in the basolateral amygdala are associated with susceptibility to depressive disorder in the presence of stressful experiences in early life.
Title: FKBP5 and specific microRNAs via glucocorticoid receptor in the basolateral amygdala involved in the susceptibility to depressive disorder in early adolescent stressed rats.
This study demonstrate that lowering FKBP5 expression in infralimbic prefrontal cortex is sufficient to both reduce fear acquisition and enhance extinction, and suggest that lower expression of FKBP5 in the ventral medial prefrontal cortex .
Title: Dynamic expression of FKBP5 in the medial prefrontal cortex regulates resiliency to conditioned fear.
Sequential and tandem ChIP analyses showed that, after forced swim (FS) stress , MRs and GRs bind concomitantly to the same GRE sites within Fkbp5 and Per1 but not Sgk1 Thus, after stress, MRs and GRs seem to bind to GREs as homo- and/or heterodimers in a gene-dependent manner. MR binding to GREs at baseline seems to be restricted, whereas after stress, GR binding may facilitate cobinding of MR
Title: Acute stress enhances heterodimerization and binding of corticosteroid receptors at glucocorticoid target genes in the hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

D20Wox13 (e-PCR)
- UniSTS:518704

AU027010 (e-PCR)
- UniSTS:113717

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP5

Names: FK506 binding protein 5

NP_001012174.1

EC 5.2.1.8

XP_006256284.1

EC 5.2.1.8

XP_006256286.1

EC 5.2.1.8

XP_038954747.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012174.2 → NP_001012174.1 peptidyl-prolyl cis-trans isomerase FKBP5

See identical proteins and their annotated locations for NP_001012174.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

Q5U2T9

Conserved Domains (5) summary

smart00028
Location:319 → 350

TPR; Tetratricopeptide repeats

sd00006
Location:319 → 345

TPR; TPR repeat [structural motif]

pfam00254
Location:44 → 135

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

pfam00515
Location:352 → 384

TPR_1; Tetratricopeptide repeat

pfam13414
Location:319 → 382

TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

6458931..6577227 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256224.5 → XP_006256286.1 peptidyl-prolyl cis-trans isomerase FKBP5 isoform X3

See identical proteins and their annotated locations for XP_006256286.1

UniProtKB/TrEMBL

Q5U2T9

Conserved Domains (5) summary

smart00028
Location:319 → 350

TPR; Tetratricopeptide repeats

sd00006
Location:319 → 345

TPR; TPR repeat [structural motif]

pfam00254
Location:44 → 135

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

pfam00515
Location:352 → 384

TPR_1; Tetratricopeptide repeat

pfam13414
Location:319 → 382

TPR_11; TPR repeat
XM_039098819.2 → XP_038954747.1 peptidyl-prolyl cis-trans isomerase FKBP5 isoform X2

UniProtKB/TrEMBL

A0A8I5ZX46

Related

ENSRNOP00000084395.1, ENSRNOT00000109678.2

Conserved Domains (3) summary

TIGR00990
Location:246 → 413

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:335 → 361

TPR; TPR repeat [structural motif]

pfam00254
Location:60 → 151

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
XM_006256222.5 → XP_006256284.1 peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1

UniProtKB/TrEMBL

F7EYK0

Related

ENSRNOP00000034024.5, ENSRNOT00000033119.7

Conserved Domains (5) summary

smart00028
Location:336 → 367

TPR; Tetratricopeptide repeats

sd00006
Location:336 → 362

TPR; TPR repeat [structural motif]

pfam00254
Location:61 → 152

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

pfam00515
Location:369 → 401

TPR_1; Tetratricopeptide repeat

pfam13414
Location:336 → 399

TPR_11; TPR repeat