Ip6k2 inositol hexakisphosphate kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ip6k2provided by RGD
Official Full Name: inositol hexakisphosphate kinase 2provided by RGD
Primary source: RGD:620529
See related: EnsemblRapid:ENSRNOG00000020361 AllianceGenome:RGD:620529
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pius; Ihpk2
Summary: Predicted to enable flavonoid binding activity and inositol hexakisphosphate 5-kinase activity. Involved in phosphate ion transport. Predicted to be located in cell junction; fibrillar center; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human IP6K2 (inositol hexakisphosphate kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 179.7), Thymus (RPKM 158.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (118362154..118388668)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (109483843..109510172)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (117574136..117599849)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:532317

Ip6k2 (e-PCR), detects polymorphism
- UniSTS:532317

RH144690 (e-PCR)
- UniSTS:233935

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables flavonoid binding	IEA Inferred from Electronic Annotation more info
enables flavonoid binding	ISO Inferred from Sequence Orthology more info
enables flavonoid binding	ISS Inferred from Sequence or Structural Similarity more info
enables inositol hexakisphosphate 5-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol hexakisphosphate 5-kinase activity	ISO Inferred from Sequence Orthology more info
enables inositol hexakisphosphate 5-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol hexakisphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol hexakisphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to flavonoid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to flavonoid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to flavonoid	ISS Inferred from Sequence or Structural Similarity more info
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in inositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in inositol phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in inositol phosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inositol hexakisphosphate kinase 2

Names: InsP6 kinase 2; P(i)-uptake stimulator; inositol hexaphosphate kinase 2

NP_067692.2

EC 2.7.4.21

XP_008764786.1

EC 2.7.4.21

XP_038937971.1

EC 2.7.4.21

XP_038937972.1

EC 2.7.4.21

XP_038937973.1

EC 2.7.4.21

XP_063122126.1

EC 2.7.4.21

XP_063122127.1

EC 2.7.4.21

XP_063122128.1

EC 2.7.4.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431589.1 → NP_001418518.1 inositol hexakisphosphate kinase 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q5XIU6, Q9R0U1

UniProtKB/TrEMBL

A6I382
NM_021660.3 → NP_067692.2 inositol hexakisphosphate kinase 2

See identical proteins and their annotated locations for NP_067692.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q5XIU6, Q9R0U1

UniProtKB/TrEMBL

A0A8L2UKG6, A6I382

Related

ENSRNOP00000071056.1, ENSRNOT00000077078.3

Conserved Domains (1) summary

pfam03770
Location:202 → 417

IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

118362154..118388668

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082045.2 → XP_038937973.1 inositol hexakisphosphate kinase 2 isoform X4

UniProtKB/TrEMBL

A6I383
XM_039082044.2 → XP_038937972.1 inositol hexakisphosphate kinase 2 isoform X2
XM_008766564.4 → XP_008764786.1 inositol hexakisphosphate kinase 2 isoform X1

Related

ENSRNOP00000027584.5, ENSRNOT00000027584.6

Conserved Domains (1) summary

pfam03770
Location:202 → 417

IPK; Inositol polyphosphate kinase
XM_063266057.1 → XP_063122127.1 inositol hexakisphosphate kinase 2 isoform X3
XM_063266056.1 → XP_063122126.1 inositol hexakisphosphate kinase 2 isoform X1

UniProtKB/Swiss-Prot

Q5XIU6, Q9R0U1

UniProtKB/TrEMBL

A6I382
XM_039082043.2 → XP_038937971.1 inositol hexakisphosphate kinase 2 isoform X1

UniProtKB/Swiss-Prot

Q5XIU6, Q9R0U1

UniProtKB/TrEMBL

A0A8L2UKG6, A6I382

Conserved Domains (1) summary

pfam03770
Location:202 → 417

IPK; Inositol polyphosphate kinase
XM_063266058.1 → XP_063122128.1 inositol hexakisphosphate kinase 2 isoform X3