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    Ehf ets homologous factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ehfprovided by RGD
    Official Full Name
    ets homologous factorprovided by RGD
    Primary source
    RGD:1310282
    See related
    EnsemblRapid:ENSRNOG00000007484 AllianceGenome:RGD:1310282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in epithelial cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in nucleus. Used to study abdominal aortic aneurysm. Orthologous to human EHF (ETS homologous factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 48.1), Kidney (RPKM 46.8) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ehf in Genome Data Viewer
    Location:
    3q32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (110094770..110134991, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (89639845..89680061, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (93176257..93216484, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene APAF1 interacting protein Neighboring gene RNA, U6 small nuclear 434 Neighboring gene uncharacterized LOC102548892 Neighboring gene E74 like ETS transcription factor 5 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene catalase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors. Nakashima H, et al. Circulation, 2004 Jan 6. PMID 14662712
    2. ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. Kas K, et al. J Biol Chem, 2000 Jan 28. PMID 10644770
    3. ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites. Lim JH, et al. Biochem Biophys Res Commun, 2006 Nov 24. PMID 17027647
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ETS homologous factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106493.3 → NP_001099963.1  ETS homologous factor isoform 1

      See identical proteins and their annotated locations for NP_001099963.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZQ62, B2RYD8, F7F464
      Related
      ENSRNOP00000010580.4, ENSRNOT00000010580.8
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    2. NM_001429956.1 → NP_001416885.1  ETS homologous factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZQ62

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      110094770..110134991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234641.5 → XP_006234703.1  ETS homologous factor isoform X1

      Conserved Domains (2) summary
      smart00413
      Location:205 → 292
      ETS; erythroblast transformation specific domain
      cl15755
      Location:39 → 116
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_039104530.2 → XP_038960458.1  ETS homologous factor isoform X2

      UniProtKB/TrEMBL
      A6HNR1
      Conserved Domains (2) summary
      smart00413
      Location:119 → 206
      ETS; erythroblast transformation specific domain
      cl15755
      Location:1 → 29
      SAM_superfamily; SAM (Sterile alpha motif )

    RNA

    1. XR_005501812.2 RNA Sequence

    2. XR_005501811.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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