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    Dis3l2 DIS3-like 3'-5' exoribonuclease 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367307, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dis3l2provided by RGD
    Official Full Name
    DIS3-like 3'-5' exoribonuclease 2provided by RGD
    Primary source
    RGD:1560168
    See related
    EnsemblRapid:ENSRNOG00000018931 AllianceGenome:RGD:1560168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560168
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity; magnesium ion binding activity; and poly(U) RNA binding activity. Predicted to be involved in several processes, including RNA catabolic process; mitotic sister chromatid separation; and stem cell population maintenance. Predicted to be located in cytoplasm. Predicted to be active in P-body. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 119.1), Brain (RPKM 106.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dis3l2 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (94802056..95184523)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (87355409..87736616)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (93767837..94161106)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480605 Neighboring gene natriuretic peptide C Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 1 Neighboring gene ribosomal protein L21, pseudogene 1 Neighboring gene alkaline phosphatase, germ cell Neighboring gene alkaline phosphatase, placental

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs. Ustianenko D, et al. RNA, 2013 Dec. PMID 24141620, Free PMC Article
    2. A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Chang HM, et al. Nature, 2013 May 9. PMID 23594738, Free PMC Article
    3. Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility. Astuti D, et al. Nat Genet, 2012 Feb 5. PMID 22306653
    4. Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway. Faehnle CR, et al. Nature, 2014 Oct 9. PMID 25119025, Free PMC Article
    5. Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA. Lubas M, et al. EMBO J, 2013 Jul 3. PMID 23756462, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA nuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polyuridylation-dependent mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DIS3-like exonuclease 2
    Names
    DIS3 mitotic control homolog-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109007.2 → NP_001102477.2  DIS3-like exonuclease 2 isoform 1

      See identical proteins and their annotated locations for NP_001102477.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CH474004
      UniProtKB/TrEMBL
      A0A0G2K6W6, A6JWJ8
      Related
      ENSRNOP00000073968.2, ENSRNOT00000084590.3
      Conserved Domains (2) summary
      COG0557
      Location:238 → 824
      VacB; Exoribonuclease R [Transcription]
      pfam17216
      Location:50 → 159
      Rrp44_CSD1; Rrp44-like cold shock domain

    2. NM_001172159.1 → NP_001165630.1  DIS3-like exonuclease 2 isoform 2

      See identical proteins and their annotated locations for NP_001165630.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      CH474004
      UniProtKB/TrEMBL
      A6JWJ9, D3ZIL9
      Related
      ENSRNOP00000025779.4, ENSRNOT00000025779.7
      Conserved Domains (2) summary
      COG0557
      Location:224 → 810
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:369 → 717
      RNB; RNB domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      94802056..95184523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083980.2 → XP_038939908.1  DIS3-like exonuclease 2 isoform X3

      Conserved Domains (2) summary
      COG0557
      Location:238 → 746
      VacB; Exoribonuclease R [Transcription]
      pfam17216
      Location:50 → 159
      Rrp44_CSD1; Rrp44-like cold shock domain

    2. XM_063267518.1 → XP_063123588.1  DIS3-like exonuclease 2 isoform X4

      Related
      ENSRNOP00000090230.2, ENSRNOT00000116589.2

    3. XM_039083979.2 → XP_038939907.1  DIS3-like exonuclease 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6W6, A6JWJ8
      Conserved Domains (2) summary
      COG0557
      Location:238 → 824
      VacB; Exoribonuclease R [Transcription]
      pfam17216
      Location:50 → 159
      Rrp44_CSD1; Rrp44-like cold shock domain

    4. XM_063267517.1 → XP_063123587.1  DIS3-like exonuclease 2 isoform X2

      UniProtKB/TrEMBL
      A6JWJ9, D3ZIL9

    5. XM_039083981.2 → XP_038939909.1  DIS3-like exonuclease 2 isoform X5

      UniProtKB/TrEMBL
      A6JWK0
      Conserved Domains (1) summary
      COG0557
      Location:37 → 623
      VacB; Exoribonuclease R [Transcription]
    Nucleotide Protein Strain
    Heading Accession and Version

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