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    Cluh clustered mitochondria homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303300, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cluhprovided by RGD
    Official Full Name
    clustered mitochondria homologprovided by RGD
    Primary source
    RGD:1307222
    See related
    EnsemblRapid:ENSRNOG00000002669 AllianceGenome:RGD:1307222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307222
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in intracellular distribution of mitochondria and mitochondrion organization. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Orthologous to human CLUH (clustered mitochondria homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 381.2), Kidney (RPKM 280.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cluh in Genome Data Viewer
    Location:
    10q24
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60008052..60029742)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (59509580..59531345)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (61432872..61454445)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 92B Neighboring gene ATP synthase subunit e, mitochondrial-like Neighboring gene uncharacterized LOC134480822 Neighboring gene platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins. Gao J, et al. J Cell Biol, 2014 Oct 27. PMID 25349259, Free PMC Article
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular distribution of mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular distribution of mitochondria ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    clustered mitochondria protein homolog
    Names
    clustered mitochondria (cluA/CLU1) homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305213.1 → NP_001292142.1  clustered mitochondria protein homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0U1RRV5, A0A8I6ARR0
      Related
      ENSRNOP00000075826.1, ENSRNOT00000092478.3
      Conserved Domains (6) summary
      sd00006
      Location:1062 → 1088
      TPR; TPR repeat [structural motif]
      pfam12807
      Location:809 → 988
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:394 → 614
      CLU; Clustered mitochondria
      pfam13374
      Location:1061 → 1100
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:1140 → 1217
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:104 → 177
      CLU_N; Mitochondrial function, CLU-N-term

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      60008052..60029742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269055.1 → XP_063125125.1  clustered mitochondria protein homolog isoform X4

      UniProtKB/TrEMBL
      A0A8I6ARR0

    2. XM_063269054.1 → XP_063125124.1  clustered mitochondria protein homolog isoform X3

      UniProtKB/TrEMBL
      A0A0U1RRV5, A0A8I6ARR0

    3. XM_063269057.1 → XP_063125127.1  clustered mitochondria protein homolog isoform X5

      UniProtKB/TrEMBL
      A0A8I6ARR0

    4. XM_063269056.1 → XP_063125126.1  clustered mitochondria protein homolog isoform X5

      UniProtKB/TrEMBL
      A0A8I6ARR0
      Related
      ENSRNOP00000096027.2, ENSRNOT00000115825.2

    5. XM_063269058.1 → XP_063125128.1  clustered mitochondria protein homolog isoform X5

      UniProtKB/TrEMBL
      A0A8I6ARR0

    6. XM_063269053.1 → XP_063125123.1  clustered mitochondria protein homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I6ARR0

    7. XM_063269051.1 → XP_063125121.1  clustered mitochondria protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARR0

    8. XM_063269059.1 → XP_063125129.1  clustered mitochondria protein homolog isoform X6

      UniProtKB/TrEMBL
      A0A8I6ARR0
    Nucleotide Protein Strain
    Heading Accession and Version

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