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    Vsp37A Vacuolar protein sorting 37A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vsp37Aprovided by FlyBase
    Official Full Name
    Vacuolar protein sorting 37Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016038
    Locus tag
    Dmel_CG17828
    See related
    AllianceGenome:FB:FBgn0016038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0153538.78; CG17828; Dmel\CG17828; EG:115C2.5; mod(r); Vps37; vps37A
    Summary
    Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT I complex. Is expressed in embryonic/larval midgut and organism. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 53. Orthologous to human VPS37A (VPS37A subunit of ESCRT-I). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vsp37A in Genome Data Viewer
    Location:
    1B12-1B12; 1-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (621530..623051)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (515563..517084)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45474 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45475 Neighboring gene uncharacterized protein Neighboring gene Histone H4 transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modifier of rudimentary p1, mod(r)p1, a trans-acting regulatory mutation of rudimentary. Begley D, et al. Mol Gen Genet, 1995 Jul 22. PMID 7651329
    2. The Endosomal Sorting Complex, ESCRT, has diverse roles in blood progenitor maintenance, lineage choice and immune response. Ray A, et al. Biol Open, 2024 Jun 15. PMID 38828842, Free PMC Article
    3. Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. Vaccari T, et al. J Cell Sci, 2009 Jul 15. PMID 19571114, Free PMC Article
    4. Developmental and cellular functions of the ESCRT machinery in pluricellular organisms. Michelet X, et al. Biol Cell, 2010 Jan 13. PMID 20059450
    5. The role of the endosomal sorting complexes required for transport (ESCRT) in tumorigenesis. Mattissek C, et al. Mol Membr Biol, 2014 Jun. PMID 24641493, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT I complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar protein sorting 37A
    Names
    CG17828-PA
    CG17828-PB
    CG17828-PC
    CG17828-PD
    CG17828-PE
    CG17828-PF
    Vsp37A-PA
    Vsp37A-PB
    Vsp37A-PC
    Vsp37A-PD
    Vsp37A-PE
    Vsp37A-PF
    modifier of rudimentary

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      621530..623051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080295.3 → NP_525034.2  vacuolar protein sorting 37A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525034.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77259, Q9N6W9
      Related
      FBpp0088667
      Conserved Domains (1) summary
      pfam07200
      Location:42 → 181
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    2. NM_166850.2 → NP_726681.1  vacuolar protein sorting 37A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726681.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZA5, Q9N6W9
      Related
      FBpp0088665
      Conserved Domains (1) summary
      pfam07200
      Location:42 → 177
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    3. NM_166848.2 → NP_726679.1  vacuolar protein sorting 37A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726679.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77259, Q9N6W9
      Related
      FBpp0088666
      Conserved Domains (1) summary
      pfam07200
      Location:42 → 181
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    4. NM_001272172.1 → NP_001259101.1  vacuolar protein sorting 37A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259101.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77259, Q9N6W9
      Conserved Domains (1) summary
      pfam07200
      Location:42 → 181
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    5. NM_001272171.1 → NP_001259100.1  vacuolar protein sorting 37A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259100.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZA5, Q9N6W9
      Conserved Domains (1) summary
      pfam07200
      Location:42 → 177
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    6. NM_166849.2 → NP_726680.1  vacuolar protein sorting 37A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726680.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZA5, Q9N6W9
      Related
      FBpp0088664
      Conserved Domains (1) summary
      pfam07200
      Location:42 → 177
      Mod_r; Modifier of rudimentary (Mod(r)) protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77259 O77259
    Q7YZA5 Q7YZA5
    Q9N6W9 Q9N6W9

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