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    Cdkl4 cyclin-dependent kinase-like 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 503009, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cdkl4provided by RGD
    Official Full Name
    cyclin-dependent kinase-like 4provided by RGD
    Primary source
    RGD:1583704
    See related
    EnsemblRapid:ENSRNOG00000040266 AllianceGenome:RGD:1583704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be active in nucleus. Orthologous to human CDKL4 (cyclin dependent kinase like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 33.9), Lung (RPKM 19.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdkl4 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20202047..20244821)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14449822..14492568)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (3232278..3272454, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551891 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 3 Neighboring gene eukaryotic translation initiation factor 1-like Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene uncharacterized LOC134479101

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase-like 4
    XP_038968990.1
    XP_038968991.1
    XP_038968992.1
    XP_038968993.1
    XP_038968994.1
    XP_038968996.1
    XP_063118641.1
    XP_063118642.1
    XP_063118643.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432117.1 → NP_001419046.1  cyclin-dependent kinase-like 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZVG4

    2. NM_001432118.1 → NP_001419047.1  cyclin-dependent kinase-like 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      F1LYD6

    3. NM_001432119.1 → NP_001419048.1  cyclin-dependent kinase-like 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZVG4

    4. NM_001432120.1 → NP_001419049.1  cyclin-dependent kinase-like 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      F1LYD6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      20202047..20244821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113065.2 → XP_038968993.1  cyclin-dependent kinase-like 4 isoform X1

      Conserved Domains (1) summary
      cd07847
      Location:2 → 286
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    2. XM_063262573.1 → XP_063118643.1  cyclin-dependent kinase-like 4 isoform X2

    3. XM_039113062.2 → XP_038968990.1  cyclin-dependent kinase-like 4 isoform X1

      Conserved Domains (1) summary
      cd07847
      Location:2 → 286
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    4. XM_039113068.2 → XP_038968996.1  cyclin-dependent kinase-like 4 isoform X2

      Conserved Domains (1) summary
      cd07847
      Location:2 → 285
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    5. XM_063262572.1 → XP_063118642.1  cyclin-dependent kinase-like 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVG4
      Related
      ENSRNOP00000058687.3, ENSRNOT00000061975.3

    6. XM_039113066.2 → XP_038968994.1  cyclin-dependent kinase-like 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVG4
      Conserved Domains (1) summary
      cd07847
      Location:2 → 286
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    7. XM_039113063.2 → XP_038968991.1  cyclin-dependent kinase-like 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVG4
      Conserved Domains (1) summary
      cd07847
      Location:2 → 286
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    8. XM_063262571.1 → XP_063118641.1  cyclin-dependent kinase-like 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVG4

    9. XM_039113064.2 → XP_038968992.1  cyclin-dependent kinase-like 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVG4
      Conserved Domains (1) summary
      cd07847
      Location:2 → 286
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
    Nucleotide Protein Strain
    Heading Accession and Version

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