Cyp18a1 Cytochrome P450 18a1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cyp18a1provided by FlyBase
Official Full Name: Cytochrome P450 18a1provided by FlyBase
Primary source: FLYBASE:FBgn0010383
Locus tag: Dmel_CG6816
See related: AllianceGenome:FB:FBgn0010383
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 181H6T; 18a1; 26-hyd; CG6816; CT20826; cyp18; Cyp18; CYP18; cyp18a1; Cyp18A1; CYP18A1; CYP18A1-Dm; Cyt-P450-17C; CytP450; Dmel\CG6816; Eig17-1; ESTS:181H6T; P-450; P450
Summary: Enables steroid hydroxylase activity. Involved in chorion-containing eggshell formation and instar larval or pupal development. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic epipharynx; epithelium; gland; and gut section. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); extrapyramidal and movement disease; hereditary spastic paraplegia 56; and leukemia (multiple). Orthologous to several human genes including CYP2U1 (cytochrome P450 family 2 subfamily U member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 17D1-17D1; 1-60 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18688538..18693042, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18582571..18587075, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

demonstrate that Drosophila melanogaster Cyp18a1 encodes a cytochrome P450 enzyme (CYP) with 26-hydroxylase activity, a prominent step in ecdysteroid catabolism
Title: CYP18A1, a key enzyme of Drosophila steroid hormone inactivation, is essential for metamorphosis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables steroid hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chorion-containing eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ecdysteroid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metamorphosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prepupal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info