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    Myl9 myosin light chain 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296313, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Myl9provided by RGD
    Official Full Name
    myosin light chain 9provided by RGD
    Primary source
    RGD:1311235
    See related
    EnsemblRapid:ENSRNOG00000020246 AllianceGenome:RGD:1311235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable myosin heavy chain binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in myofibril assembly; platelet aggregation; and stress fiber assembly. Predicted to be located in Z disc. Predicted to be part of myosin II complex. Predicted to be active in myofibril and stress fiber. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to human MYL9 (myosin light chain 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 1884.6), Heart (RPKM 1193.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myl9 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (165742020..165748409)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (145281943..145288333)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (152857573..152863961)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486192 Neighboring gene DLG associated protein 4 Neighboring gene uncharacterized LOC103691945 Neighboring gene uncharacterized LOC102551821 Neighboring gene uncharacterized LOC120101767 Neighboring gene TGFB-induced factor homeobox 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dynamic regulation of vascular myosin light chain (MYL9) with injury and aging. Shehadeh LA, et al. PLoS One, 2011. PMID 22003410, Free PMC Article
    2. The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice. Szczesna-Cordary D, et al. J Cell Sci, 2005 Aug 15. PMID 16076902
    3. Genes up-regulated in hypertrophied ventricle. Iwai N, et al. Biochem Biophys Res Commun, 1995 Apr 17. PMID 7733921
    4. Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor. Lu Z, et al. J Biol Chem, 2014 Jun 27. PMID 24825904, Free PMC Article
    5. Myosin regulatory light chains are required to maintain the stability of myosin II and cellular integrity. Park I, et al. Biochem J, 2011 Feb 15. PMID 21126233

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. consistent upregulation of the myosin light chain protein (Myl9) with age and injury
      Title: Dynamic regulation of vascular myosin light chain (MYL9) with injury and aging.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin heavy chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin II complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin II complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myosin regulatory light polypeptide 9
    Names
    myosin regulatory light chain 9
    myosin, light chain 9, regulatory
    myosin, light polypeptide 9, regulatory

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100885.3 → NP_001094355.2  myosin regulatory light polypeptide 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q64122
      UniProtKB/TrEMBL
      B0BMS8, F7F3J1
      Conserved Domains (1) summary
      COG5126
      Location:19 → 169
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_001430178.1 → NP_001417107.1  myosin regulatory light polypeptide 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q64122
      UniProtKB/TrEMBL
      B0BMS8, F7F3J1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      165742020..165748409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235402.4 → XP_006235464.1  myosin regulatory light polypeptide 9 isoform X1

      Related
      ENSRNOP00000027445.5, ENSRNOT00000027445.9
      Conserved Domains (1) summary
      COG5126
      Location:19 → 169
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64122.2 GenPept UniProtKB/Swiss-Prot:Q64122

    Gene LinkOut

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