Lbp lipopolysaccharide binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lbpprovided by RGD
Official Full Name: lipopolysaccharide binding proteinprovided by RGD
Primary source: RGD:61865
See related: EnsemblRapid:ENSRNOG00000014532 AllianceGenome:RGD:61865
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bpifd2
Summary: Enables lipopolysaccharide binding activity. Involved in several processes, including positive regulation of macrophage activation; positive regulation of phagocytosis, engulfment; and response to ethanol. Located in extracellular space. Used to study obesity. Biomarker of liver cirrhosis; metabolic dysfunction and alcohol associated liver disease; obstructive jaundice; and periodontitis. Orthologous to human LBP (lipopolysaccharide binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 304.4), Heart (RPKM 58.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (167373786..167400941)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (146953889..146981032)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (154786232..154812910)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPbeta- SCD activation in non-alcoholic fatty liver disease.
Title: Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ- SCD activation in non-alcoholic fatty liver disease.
The characteristic regulation of gene expression Lbp and Sod3 in peri-implant connective tissue of rats.
Title: The characteristic regulation of gene expression Lbp and Sod3 in peri-implant connective tissue of rats.
LBP has a role in augmentation of the host's response in a rat sepsis model via G-CSF
Title: Lipopolysaccharide-binding protein (LBP) blockade augments the protective effect of granulocyte colony-stimulating factor (G-CSF) in a rat sepsis model.
Hepatic LBP mRNA expression increased significantly at five days after bile duct ligation.
Title: The kinetic expression of lipopolysaccharide-binding protein and CD14 gene in obstructive jaundice.
these findings suggest that translocation of Lipopolysaccharide occurs after liver transplantation and that lipopolysaccharide binding protein is mediating the LPS-induced inflammatory response after liver transplantation.
Title: Liver transplantation and inflammation: is lipopolysaccharide binding protein the link?
G-CSF induced LBP expression could serve as a new model for investigation of LPS sensitization. We demonstrated the crucial role of LBP upregulation in pathogenesis of LPS induced SIRS.
Title: Granulocyte colony stimulating factor induces lipopolysaccharide (LPS) sensitization via upregulation of LPS binding protein in rat.
lipopolysaccharide disrupts the tight junction of a bile duct epithelial monolayer by a c-Src-, TLR4-, LBP-, and myosin light chain kinase-dependent mechanism.
Title: Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism.
This proteins do not bind monophosphoryl lipid A. Diphosphoryl lipid A binding occurs in the absence of serum in Kupffer cells.
Title: Identification of two novel LPS-binding proteins in Kupffer cells: implications in TNF-alpha production.
Effects of LPS on quiescent hepatic stellate cells are novel, occurring without the aid of LBP/CD14.
Title: Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes.
the ability of SP-A to inhibit immune cell activation by Re-LPS may be due to its ability to block the binding of Re-LPS to LBP and prevent the initiation of the LBP/CD14 pathway for inflammatory reactions in the lung
Title: Surfactant protein a inhibits lipopolysaccharide-induced immune cell activation by preventing the interaction of lipopolysaccharide with lipopolysaccharide-binding protein.

Submit: New GeneRIF Correction

General gene information

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Markers

D3Got121 (e-PCR)
- UniSTS:111730

D3Got125 (e-PCR)
- UniSTS:112884

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables lipopeptide binding	IEA Inferred from Electronic Annotation more info
enables lipopeptide binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables lipopolysaccharide binding	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables lipoteichoic acid binding	IEA Inferred from Electronic Annotation more info
enables lipoteichoic acid binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute-phase response	IBA Inferred from Biological aspect of Ancestor more info
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in acute-phase response	ISO Inferred from Sequence Orthology more info
involved_in cell surface pattern recognition receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lipoteichoic acid	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to lipoteichoic acid	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in detection of molecule of bacterial origin	IEA Inferred from Electronic Annotation more info
involved_in detection of molecule of bacterial origin	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in leukocyte chemotaxis involved in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukocyte chemotaxis involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipopolysaccharide transport	IEA Inferred from Electronic Annotation more info
involved_in lipopolysaccharide transport	ISO Inferred from Sequence Orthology more info
involved_in lipopolysaccharide-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in macrophage activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of respiratory burst involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of respiratory burst involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 4 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lipopolysaccharide-binding protein

Names: BPI fold containing family D, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017208.2 → NP_058904.2 lipopolysaccharide-binding protein precursor

See identical proteins and their annotated locations for NP_058904.2

Status: PROVISIONAL

Source sequence(s)

BC101906

UniProtKB/Swiss-Prot

Q63313

UniProtKB/TrEMBL

F7FLI1, Q3MID7

Related

ENSRNOP00000019787.1, ENSRNOT00000019787.4

Conserved Domains (2) summary

cd00025
Location:31 → 252

BPI1; BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...

pfam02886
Location:241 → 478

LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

167373786..167400941

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104447.2 → XP_038960375.1 lipopolysaccharide-binding protein isoform X2

Conserved Domains (2) summary

cd00025
Location:31 → 252

BPI1; BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...

cl00188
Location:241 → 307

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
XM_039104446.2 → XP_038960374.1 lipopolysaccharide-binding protein isoform X1

Conserved Domains (2) summary

smart00328
Location:2 → 134

BPI1; BPI/LBP/CETP N-terminal domain

pfam02886
Location:119 → 356

LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain
XM_039104448.2 → XP_038960376.1 lipopolysaccharide-binding protein isoform X3

Conserved Domains (2) summary

pfam02886
Location:42 → 279

LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain

cl00188
Location:1 → 57

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...