Fbxo5 F-box protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fbxo5provided by RGD
Official Full Name: F-box protein 5provided by RGD
Primary source: RGD:1309405
See related: EnsemblRapid:ENSRNOG00000024077 AllianceGenome:RGD:1309405
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable anaphase-promoting complex binding activity; protein kinase binding activity; and ubiquitin ligase inhibitor activity. Predicted to be involved in several processes, including negative regulation of metabolic process; positive regulation of mesenchymal stem cell migration; and regulation of cell cycle process. Predicted to act upstream of or within several processes, including microtubule cytoskeleton organization; negative regulation of meiotic nuclear division; and oocyte maturation. Predicted to be located in cytoplasm; meiotic spindle; and nucleoplasm. Orthologous to human FBXO5 (F-box protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 180.9), Spleen (RPKM 124.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (44601412..44607781, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (42196068..42202437, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (42461277..42467646, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Marked reductions in both RNA and protein levels of Emi1 (early mitotic inhibitor 1) were also detected in Tbeta4 -downregulated IEC-6 cells.
Title: Thymosin beta-4 knockdown in IEC-6 normal intestinal epithelial cells induces DNA re-replication via downregulating Emi1.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127160 (e-PCR)
- UniSTS:208485

RH143642 (e-PCR)
- UniSTS:232888

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin ligase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA endoreduplication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic metaphase/anaphase transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of biomineral tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal stem cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spindle assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spindle assembly involved in female meiosis I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in meiotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box only protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.