Irf7 interferon regulatory factor 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Irf7provided by RGD
Official Full Name: interferon regulatory factor 7provided by RGD
Primary source: RGD:1307828
See related: EnsemblRapid:ENSRNOG00000017414 AllianceGenome:RGD:1307828
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of macromolecule biosynthetic process; and regulation of innate immune response. Predicted to act upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon production; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 506.0), Lung (RPKM 159.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205796956..205800543, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196367380..196370943, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (214249388..214252909, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury.
Title: Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury.
Interferon regulatory factor 7 inhibits rat vascular smooth muscle cell proliferation and inflammation in monocrotaline-induced pulmonary hypertension.
Title: Interferon regulatory factor 7 inhibits rat vascular smooth muscle cell proliferation and inflammation in monocrotaline-induced pulmonary hypertension.
Isolation rearing and a peripubertal immune challenge increase Irf7 expression in the rat hippocampal gyrus.
Title: Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC154027P4 (e-PCR)
- UniSTS:271287

PMC114617P2 (e-PCR)
- UniSTS:270275

RH129676 (e-PCR)
- UniSTS:212973

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in immune system process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of MyD88-dependent toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of MyD88-independent toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of adaptive immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon regulatory factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033691.1 → NP_001028863.1 interferon regulatory factor 7

See identical proteins and their annotated locations for NP_001028863.1

Status: PROVISIONAL

Source sequence(s)

BC104686

UniProtKB/TrEMBL

F7FGY2, Q3SWU2

Related

ENSRNOP00000023504.6, ENSRNOT00000023504.8

Conserved Domains (2) summary

pfam00605
Location:11 → 121

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:240 → 418

IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

205796956..205800543 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230540.3 → XP_006230602.1 interferon regulatory factor 7 isoform X1

See identical proteins and their annotated locations for XP_006230602.1

UniProtKB/TrEMBL

F7FGY2, Q3SWU2

Conserved Domains (2) summary

pfam00605
Location:11 → 121

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:240 → 418

IRF-3; Interferon-regulatory factor 3
XM_006230541.2 → XP_006230603.1 interferon regulatory factor 7 isoform X2

Conserved Domains (2) summary

pfam00605
Location:11 → 121

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:208 → 386

IRF-3; Interferon-regulatory factor 3