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    Akr1b10 aldo-keto reductase family 1 member B10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296972, updated on 27-Dec-2024

    Summary

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    Symbol
    Akr1b10provided by RGD
    Full Name
    aldo-keto reductase family 1 member B10provided by RGD
    Primary source
    RGD:1308277
    See related
    EnsemblRapid:ENSRNOG00000009734 AllianceGenome:RGD:1308277
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables NADP binding activity; alcohol dehydrogenase (NADP+) activity; and retinal binding activity. Involved in polyol metabolic process; retinal metabolic process; and retinol metabolic process. Predicted to be located in extracellular region and lysosome. Predicted to be active in cytosol. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 1546.2), Kidney (RPKM 276.7) and 3 other tissues See more
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    Genomic context

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    See Akr1b10 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (64005632..64027860)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (63038459..63060336)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (61813265..61830371)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member B8 Neighboring gene uncharacterized LOC134486751 Neighboring gene myosin light chain 6, pseudogene 4 Neighboring gene aldo-keto reductase family 1, member B7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10). Endo S, et al. Arch Biochem Biophys, 2010 Nov 15. PMID 20709016
    2. Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels. Zhong L, et al. Biochem Biophys Res Commun, 2009 Sep 18. PMID 19563777, Free PMC Article
    3. Role of human aldo-keto-reductase AKR1B10 in the protection against toxic aldehydes. Martin HJ, et al. Chem Biol Interact, 2009 Mar 16. PMID 19013440
    4. Aldo-keto reductases and bioactivation/detoxication. Jin Y, et al. Annu Rev Pharmacol Toxicol, 2007. PMID 16970545
    5. Meta-analysis of three diabetes population studies: association of inactive ALDH2 genotype with maternal inheritance of diabetes. Murata C, et al. Diabetes Res Clin Pract, 2004 Dec. PMID 15563966

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results demonstrate that Akr7a3 mRNA and protein levels are consistently co-expressed along with Akr1b10, in both experimental rat liver carcinogenesis and some human hepatocellular carcinoma samples.
      Title: Aldo-Keto Reductases as Early Biomarkers of Hepatocellular Carcinoma: A Comparison Between Animal Models and Human HCC.
    2. Properties and tissue distribution of a novel carbonyl reductase (NADPH) encoding in a rat gene are reported.
      Title: Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NADP+ binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables all-trans-retinol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables all-trans-retinol dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables geranylgeranyl reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables indanol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinal binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables retinal dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular detoxification of aldehyde ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in daunorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in doxorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in farnesol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polyol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retinal metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aldo-keto reductase family 1 member B10
    Names
    aldo-keto reductase family 1, member B10 (aldose reductase)
    aldose reductase-related protein 1-like
    NP_001013102.1
    XP_038963219.1
    XP_038963220.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013084.1 → NP_001013102.1  aldo-keto reductase family 1 member B10

      See identical proteins and their annotated locations for NP_001013102.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079133
      UniProtKB/TrEMBL
      A0A8I5ZN93, M0R8B8, Q6AY99
      Conserved Domains (1) summary
      cd19107
      Location:10 → 316
      AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      64005632..64027860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107291.2 → XP_038963219.1  aldo-keto reductase family 1 member B10 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN93, M0R8B8, Q6AY99
      Related
      ENSRNOP00000065713.1, ENSRNOT00000074951.4
      Conserved Domains (1) summary
      cd19107
      Location:10 → 316
      AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)

    2. XM_039107292.2 → XP_038963220.1  aldo-keto reductase family 1 member B10 isoform X2

      UniProtKB/TrEMBL
      A6IEM0
      Conserved Domains (1) summary
      cl00470
      Location:1 → 172
      AKR_SF; Aldo-keto reductase (AKR) superfamily

    RNA

    1. XR_001837481.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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