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    Slc41a2 solute carrier family 41 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362861, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Slc41a2provided by RGD
    Official Full Name
    solute carrier family 41 member 2provided by RGD
    Primary source
    RGD:1307292
    See related
    EnsemblRapid:ENSRNOG00000008713 AllianceGenome:RGD:1307292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable inorganic cation transmembrane transporter activity. Predicted to be involved in metal ion transport. Predicted to act upstream of or within metal ion transport. Predicted to be active in plasma membrane. Orthologous to human SLC41A2 (solute carrier family 41 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 377.6), Testes (RPKM 57.8) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc41a2 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (22271298..22378764)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (20383714..20491178)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (26522314..26607861)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S8-like Neighboring gene NOP protein chaperone 1 Neighboring gene uncharacterized LOC102550067 Neighboring gene uncharacterized LOC134479650 Neighboring gene uncharacterized LOC120093545 Neighboring gene carbohydrate sulfotransferase 11 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of the mouse [corrected] solute carrier, SLC41A2. Goytain A, et al. Biochem Biophys Res Commun, 2005 May 13. PMID 15809054
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inorganic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cobalt ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iron ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in magnesium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in manganese ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metal ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nickel cation transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 41 member 2
    Names
    solute carrier family 41 (magnesium transporter), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108742.2 → NP_001102212.1  solute carrier family 41 member 2 isoform 2

      See identical proteins and their annotated locations for NP_001102212.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6IFH1
      Related
      ENSRNOP00000011572.8, ENSRNOT00000011572.8
      Conserved Domains (1) summary
      pfam01769
      Location:389 → 529
      MgtE; Divalent cation transporter

    2. NM_001401081.1 → NP_001388010.1  solute carrier family 41 member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D4A7D4

    3. NM_001401082.1 → NP_001388011.1  solute carrier family 41 member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D4A7D4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      22271298..22378764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263757.1 → XP_063119827.1  solute carrier family 41 member 2 isoform X2

    2. XM_063263758.1 → XP_063119828.1  solute carrier family 41 member 2 isoform X2

      Related
      ENSRNOP00000102475.1, ENSRNOT00000130064.1

    3. XM_039079426.2 → XP_038935354.1  solute carrier family 41 member 2 isoform X1

      UniProtKB/TrEMBL
      D4A7D4
      Conserved Domains (1) summary
      pfam01769
      Location:413 → 554
      MgtE; Divalent cation transporter

    4. XM_039079423.2 → XP_038935351.1  solute carrier family 41 member 2 isoform X1

      UniProtKB/TrEMBL
      D4A7D4
      Conserved Domains (1) summary
      pfam01769
      Location:413 → 554
      MgtE; Divalent cation transporter

    5. XM_039079428.2 → XP_038935356.1  solute carrier family 41 member 2 isoform X2

      Conserved Domains (1) summary
      pfam01769
      Location:199 → 331
      MgtE; Divalent cation transporter

    6. XM_039079427.2 → XP_038935355.1  solute carrier family 41 member 2 isoform X3

      Related
      ENSRNOP00000108613.1, ENSRNOT00000167280.1
      Conserved Domains (1) summary
      pfam01769
      Location:199 → 331
      MgtE; Divalent cation transporter

    7. XM_039079422.2 → XP_038935350.1  solute carrier family 41 member 2 isoform X1

      UniProtKB/TrEMBL
      D4A7D4
      Related
      ENSRNOP00000099487.1, ENSRNOT00000138998.1
      Conserved Domains (1) summary
      pfam01769
      Location:413 → 554
      MgtE; Divalent cation transporter
    Nucleotide Protein Strain
    Heading Accession and Version

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