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    Foxred1 FAD-dependent oxidoreductase domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315547, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Foxred1provided by RGD
    Official Full Name
    FAD-dependent oxidoreductase domain containing 1provided by RGD
    Primary source
    RGD:1311785
    See related
    EnsemblRapid:ENSRNOG00000060379 AllianceGenome:RGD:1311785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311785
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 19. Orthologous to human FOXRED1 (FAD dependent oxidoreductase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 113.0), Muscle (RPKM 101.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Foxred1 in Genome Data Viewer
    Location:
    8q21
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (41789557..41818064, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (33551010..33560227, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (36401317..36410589, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene decapping enzyme, scavenger Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120094323 Neighboring gene TIR domain containing adaptor protein Neighboring gene SRP receptor subunit alpha Neighboring gene family with sequence similarity 118, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy. Fassone E, et al. Hum Mol Genet, 2010 Dec 15. PMID 20858599, Free PMC Article
    2. Characterization of mitochondrial FOXRED1 in the assembly of respiratory chain complex I. Formosa LE, et al. Hum Mol Genet, 2015 May 15. PMID 25678554
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FAD-dependent oxidoreductase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419933.2 → NP_001406862.1  FAD-dependent oxidoreductase domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AA73, A6JYJ8, D3ZEH2
      Related
      ENSRNOP00000070899.1, ENSRNOT00000091308.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      41789557..41818064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265417.1 → XP_063121487.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AA73, A6JYJ8, D3ZEH2

    2. XM_063265415.1 → XP_063121485.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AA73, A6JYJ8, D3ZEH2

    3. XM_063265416.1 → XP_063121486.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AA73, A6JYJ8, D3ZEH2

    4. XM_063265414.1 → XP_063121484.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AA73, A6JYJ8, D3ZEH2

    5. XM_063265412.1 → XP_063121482.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AA73, A6JYJ8, D3ZEH2

    6. XM_063265413.1 → XP_063121483.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AA73, A6JYJ8, D3ZEH2

    7. XM_056984496.2 → XP_056840476.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AA73

    8. XM_056984497.2 → XP_056840477.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AA73

    9. XM_063265421.1 → XP_063121491.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X5

    10. XM_063265419.1 → XP_063121489.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

    11. XM_063265420.1 → XP_063121490.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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