Parp9 poly (ADP-ribose) polymerase family, member 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Parp9provided by RGD
Official Full Name: poly (ADP-ribose) polymerase family, member 9provided by RGD
Primary source: RGD:1307534
See related: EnsemblRapid:ENSRNOG00000023463 AllianceGenome:RGD:1307534
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307534
Summary: Predicted to enable several functions, including ADP-D-ribose binding activity; NAD+-protein ADP-ribosyltransferase activity; and STAT family protein binding activity. Predicted to be involved in several processes, including DNA damage checkpoint signaling; regulation of defense response; and regulation of macromolecule metabolic process. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and site of DNA damage. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human PARP9 (poly(ADP-ribose) polymerase family member 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 249.3), Spleen (RPKM 170.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (78286282..78320409, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (64780977..64814995, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (67724071..67758027, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP-D-ribose binding	ISO Inferred from Sequence Orthology more info
NOT enables NAD+ binding	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables STAT family protein binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
NOT involved_in protein poly-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to type II interferon	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP9

Names: poly [ADP-ribose] polymerase 9

NP_001096821.1

EC 2.4.2.30

XP_017453484.1

EC 2.4.2.30

XP_017453485.1

EC 2.4.2.30

XP_038944271.1

EC 2.4.2.30

XP_038944274.1

EC 2.4.2.30

XP_038944275.1

EC 2.4.2.30

XP_038944279.1

EC 2.4.2.30

XP_063126587.1

EC 2.4.2.30

XP_063126588.1

EC 2.4.2.30

XP_063126589.1

EC 2.4.2.30

XP_063126590.1

EC 2.4.2.30

XP_063126591.1

EC 2.4.2.30

XP_063126592.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001103351.2 → NP_001096821.1 protein mono-ADP-ribosyltransferase PARP9

See identical proteins and their annotated locations for NP_001096821.1

Status: PROVISIONAL

Source sequence(s)

BC128756

UniProtKB/TrEMBL

A1A5Q1, A6IRE6, F1MAR0

Conserved Domains (3) summary

cd01439
Location:673 → 792

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02907
Location:83 → 243

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00019
Location:280 → 455

Macro_SF; macrodomain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

78286282..78320409 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270517.1 → XP_063126587.1 protein mono-ADP-ribosyltransferase PARP9 isoform X1

UniProtKB/TrEMBL

A0A8I5ZMQ5, A0A8I6AD67

Related

ENSRNOP00000090237.1, ENSRNOT00000116577.2
XM_039088346.2 → XP_038944274.1 protein mono-ADP-ribosyltransferase PARP9 isoform X2

UniProtKB/TrEMBL

A0A8I5Y6A7, A0A8J8Y5V1

Conserved Domains (3) summary

cd01439
Location:709 → 828

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02907
Location:119 → 279

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00019
Location:316 → 491

Macro_SF; macrodomain superfamily
XM_017597995.3 → XP_017453484.1 protein mono-ADP-ribosyltransferase PARP9 isoform X2

UniProtKB/TrEMBL

A0A8I5Y6A7, A0A8J8Y5V1

Conserved Domains (3) summary

cd01439
Location:709 → 828

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02907
Location:119 → 279

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00019
Location:316 → 491

Macro_SF; macrodomain superfamily
XM_039088347.2 → XP_038944275.1 protein mono-ADP-ribosyltransferase PARP9 isoform X2

UniProtKB/TrEMBL

A0A8I5Y6A7, A0A8J8Y5V1

Conserved Domains (3) summary

cd01439
Location:709 → 828

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02907
Location:119 → 279

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00019
Location:316 → 491

Macro_SF; macrodomain superfamily
XM_017597996.3 → XP_017453485.1 protein mono-ADP-ribosyltransferase PARP9 isoform X2

UniProtKB/TrEMBL

A0A8I5Y6A7, A0A8J8Y5V1

Conserved Domains (3) summary

cd01439
Location:709 → 828

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02907
Location:119 → 279

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00019
Location:316 → 491

Macro_SF; macrodomain superfamily
XM_063270519.1 → XP_063126589.1 protein mono-ADP-ribosyltransferase PARP9 isoform X2

UniProtKB/TrEMBL

A0A8I5Y6A7, A0A8J8Y5V1
XM_063270518.1 → XP_063126588.1 protein mono-ADP-ribosyltransferase PARP9 isoform X2

UniProtKB/TrEMBL

A0A8I5Y6A7, A0A8J8Y5V1
XM_063270521.1 → XP_063126591.1 protein mono-ADP-ribosyltransferase PARP9 isoform X5

UniProtKB/TrEMBL

A0A8I5ZMQ5, A6IRE8
XM_039088351.2 → XP_038944279.1 protein mono-ADP-ribosyltransferase PARP9 isoform X3

UniProtKB/TrEMBL

A1A5Q1, A6IRE6, F1MAR0

Conserved Domains (3) summary

cd01439
Location:673 → 792

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02907
Location:83 → 243

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00019
Location:280 → 455

Macro_SF; macrodomain superfamily
XM_063270522.1 → XP_063126592.1 protein mono-ADP-ribosyltransferase PARP9 isoform X5

UniProtKB/TrEMBL

A0A8I5ZMQ5, A6IRE8

Related

ENSRNOP00000079250.1, ENSRNOT00000113151.2
XM_039088343.2 → XP_038944271.1 protein mono-ADP-ribosyltransferase PARP9 isoform X2

UniProtKB/TrEMBL

A0A8I5Y6A7, A0A8J8Y5V1

Conserved Domains (3) summary

cd01439
Location:709 → 828

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02907
Location:119 → 279

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00019
Location:316 → 491

Macro_SF; macrodomain superfamily
XM_063270520.1 → XP_063126590.1 protein mono-ADP-ribosyltransferase PARP9 isoform X4