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    Oser1 oxidative stress responsive serine-rich 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296346, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Oser1provided by RGD
    Official Full Name
    oxidative stress responsive serine-rich 1provided by RGD
    Primary source
    RGD:1303142
    See related
    EnsemblRapid:ENSRNOG00000008297 AllianceGenome:RGD:1303142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    osr1; Perit1; RGD1303142
    Summary
    Involved in cellular response to hydrogen peroxide. Predicted to be located in nucleus. Orthologous to human OSER1 (oxidative stress responsive serine rich 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 274.1), Lung (RPKM 101.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Oser1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (172486417..172504607, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (152066975..152085180, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (159784131..159802923, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene TOX high mobility group box family member 2 Neighboring gene junctophilin 2 Neighboring gene uncharacterized LOC120101779 Neighboring gene ganglioside-induced differentiation-associated protein 1-like 1 Neighboring gene uncharacterized LOC103691964 Neighboring gene fat storage-inducing transmembrane protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cardiac myocyte gene expression profiling during H2O2-induced apoptosis. Clerk A, et al. Physiol Genomics, 2007 Apr 24. PMID 17148688
    2. Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses. Vorontsova I, et al. Invest Ophthalmol Vis Sci, 2014 Dec 16. PMID 25515571, Free PMC Article
    3. Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. Shultz MA, et al. Am J Respir Cell Mol Biol, 2004 Mar. PMID 12947022
    4. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular response to hydrogen peroxide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    oxidative stress-responsive serine-rich protein 1
    Names
    oxidative stress responsive 1
    oxidative stress-responsive protein 1
    peroxide-inducible transcript 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430198.1 → NP_001417127.1  oxidative stress-responsive serine-rich protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q703I1
      UniProtKB/TrEMBL
      A0A8L2Q532

    2. NM_001430199.1 → NP_001417128.1  oxidative stress-responsive serine-rich protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q703I1
      UniProtKB/TrEMBL
      A0A8L2Q532

    3. NM_001430200.1 → NP_001417129.1  oxidative stress-responsive serine-rich protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q703I1
      UniProtKB/TrEMBL
      A0A8L2Q532

    4. NM_201560.3 → NP_963854.1  oxidative stress-responsive serine-rich protein 1

      See identical proteins and their annotated locations for NP_963854.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q703I1
      UniProtKB/TrEMBL
      A0A8L2Q532
      Related
      ENSRNOP00000011610.5, ENSRNOT00000011610.7
      Conserved Domains (1) summary
      pfam05604
      Location:1 → 175
      DUF776; Protein of unknown function (DUF776)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      172486417..172504607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591608.3 → XP_017447097.1  oxidative stress-responsive serine-rich protein 1 isoform X1

      Conserved Domains (1) summary
      pfam05604
      Location:1 → 175
      DUF776; Protein of unknown function (DUF776)

    2. XM_039104628.2 → XP_038960556.1  oxidative stress-responsive serine-rich protein 1 isoform X1

      Conserved Domains (1) summary
      pfam05604
      Location:1 → 175
      DUF776; Protein of unknown function (DUF776)

    3. XM_063283388.1 → XP_063139458.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q703I1.1 GenPept UniProtKB/Swiss-Prot:Q703I1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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