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    Gstm3 glutathione S-transferase mu 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 57298, updated on 27-Dec-2024

    Summary

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    Symbol
    Gstm3provided by RGD
    Full Name
    glutathione S-transferase mu 3provided by RGD
    Primary source
    RGD:620381
    See related
    EnsemblRapid:ENSRNOG00000019058 AllianceGenome:RGD:620381
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gstm4; GstYb4; Gstm3l; Gstm3l1
    Summary
    Predicted to enable glutathione transferase activity and identical protein binding activity. Predicted to act upstream of or within cellular response to organic cyclic compound; cellular response to xenobiotic stimulus; and response to bacterium. Predicted to be located in cytoplasm. Biomarker of hypertension. Human ortholog(s) of this gene implicated in uterine fibroid. Orthologous to human GSTM5 (glutathione S-transferase mu 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 149.2), Testes (RPKM 106.0) and 7 other tissues See more
    Orthologs
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    Genomic context

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    See Gstm3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198295442..198300742, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (195590450..195612578, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210761729..210766501, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase mu 3 like 1 Neighboring gene uncharacterized LOC102550192 Neighboring gene glutathione S-transferase mu 2 Neighboring gene glutathione S-transferase mu 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene expression of rat glutathione S-transferases. Evidence for gene conversion in the evolution of the Yb multigene family. Lai HC, et al. J Biol Chem, 1988 Aug 15. PMID 3403534
    2. Glutathione S-transferase GSTM3 and GSTP1 genotypes and larynx cancer risk. Jourenkova-Mironova N, et al. Cancer Epidemiol Biomarkers Prev, 1999 Feb. PMID 10067818
    3. Expression profiling identifies genes involved in emphysema severity. Francis SM, et al. Respir Res, 2009 Sep 2. PMID 19723343, Free PMC Article
    4. Proteomic analysis of peripheral T-lymphocytes in patients with asthma. Jeong HC, et al. Chest, 2007 Aug. PMID 17550934
    5. Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimer's disease. Tchaikovskaya T, et al. Mech Ageing Dev, 2005 Feb. PMID 15621212

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase Mu 3
    Names
    glutathione S-transferase M3
    glutathione S-transferase M4
    glutathione S-transferase Yb4
    glutathione S-transferase mu 3-like 1
    NP_065415.2
    XP_038958931.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020540.2 → NP_065415.2  glutathione S-transferase Mu 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HUW7, D3ZVQ8, Q9WU21
      Related
      ENSRNOP00000044720.6, ENSRNOT00000051261.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      198295442..198300742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103003.2 → XP_038958931.1  glutathione S-transferase Mu 3 isoform X1

      Conserved Domains (1) summary
      cl02776
      Location:13 → 104
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    RNA

    1. XR_005500356.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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