Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ikbkbprovided by RGD
Official Full Name: inhibitor of nuclear factor kappa B kinase subunit betaprovided by RGD
Primary source: RGD:621375
See related: EnsemblRapid:ENSRNOG00000019073 AllianceGenome:RGD:621375
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IKK2; AIM-1
Summary: Enables ATP binding activity. Contributes to IkappaB kinase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; response to cholecystokinin; and response to lipopolysaccharide. Part of IkappaB kinase complex. Used to study muscular atrophy and pneumonia. Biomarker of Alzheimer's disease; colitis; colon cancer; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 138.6), Thymus (RPKM 121.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (76021968..76075717)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (69319487..69373251)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (74177233..74230809)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and NF-kappaB signaling pathways.
Title: Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and NF-κB signaling pathways.
IKBKB siRNA-Encapsulated Poly (Lactic-co-Glycolic Acid) Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial Activation.
Title: IKBKB siRNA-Encapsulated Poly (Lactic-co-Glycolic Acid) Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial Activation.
miR-218 regulates diabetic nephropathy via targeting IKK-beta and modulating NK-kappaB-mediated inflammation.
Title: miR-218 regulates diabetic nephropathy via targeting IKK-β and modulating NK-κB-mediated inflammation.
Protective effect of RNA interference targeting Ikkbeta on hepatic fibrosis in rats.
Title: Protective effect of RNA interference targeting Ikkβ on hepatic fibrosis in rats.
involved in vascular contraction through regulation of myosin light chain phosphatase activity by phosphorylating MYPT1 at thr853 in mesenteric arteries
Title: Involvement of inhibitor kappa B kinase 2 (IKK2) in the regulation of vascular tone.
Inhibition of IkappaB kinase at peak creatinine in acute kidny injury improves functional recovery, reduces further injury, and prevents fibrosis.
Title: Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis.
Overexpressed long non-coding RNA (lncRNA) ANRIL upregulates vascular endothelial growth factor (VEGF) and promotes angiogenesis by activating NF-kappa B (NF-kappaB) signaling pathway in diabetes mellitus (DM) combined with cerebral infarction (DM + CI) rats.
Title: Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-κB signaling pathway in a rat model.
Data indicate that injury-induced upregulation of inflammatory cytokines within IVDs and increased levels of neuropeptides within DRG neurons can be suppressed by inhibiting IkappaB kinase-beta (IKKbeta).
Title: Inhibiting IκB kinase-β downregulates inflammatory cytokines in injured discs and neuropeptides in dorsal root ganglia innervating injured discs in rats.
IKKbeta could reduce arterial remodeling events by affecting both the inflammatory and the growth-promoting response of Ang II.
Title: Role of IκB kinase-β in the growth-promoting effects of angiotensin II in vitro and in vivo.
H. pylori-induced ERK activation plays a critical role in up-regulation of gastric mucosal PGE2 and NO generation at the level of IKK-b and cPLA2 activation; ghrelin counters these proinflammatory events
Title: Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on MAPK/ERK-mediated activation of IKK-β and cPLA2: modulatory effect of ghrelin.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131248 (e-PCR)
- UniSTS:214531

RH139961 (e-PCR)
- UniSTS:222043

RH138696 (e-PCR)
- UniSTS:220783

BF390838 (e-PCR)
- UniSTS:249587

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
contributes_to IkappaB kinase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to IkappaB kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables IkappaB kinase activity	IEA Inferred from Electronic Annotation more info
enables IkappaB kinase activity	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables transferrin receptor binding	IEA Inferred from Electronic Annotation more info
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-1-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cation channel activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IEA Inferred from Electronic Annotation more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of endothelial barrier	IEA Inferred from Electronic Annotation more info
involved_in regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to cholecystokinin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle contraction	IEP Inferred from Expression Pattern more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CD40 receptor complex	ISO Inferred from Sequence Orthology more info
part_of IkappaB kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of IkappaB kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of IkappaB kinase complex	IEA Inferred from Electronic Annotation more info
part_of IkappaB kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inhibitor of nuclear factor kappa-B kinase subunit beta

Names: I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK-beta; NFKBIKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; nuclear factor NF-kappa-B inhibitor kinase beta; serine/threonine protein kinase IKBKB

NP_445807.2

EC 2.7.11.1

EC 2.7.11.10

XP_038950795.1

EC 2.7.11.1

EC 2.7.11.10

XP_063131856.1

EC 2.7.11.1

EC 2.7.11.10

XP_063131857.1

EC 2.7.11.1

EC 2.7.11.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053355.3 → NP_445807.2 inhibitor of nuclear factor kappa-B kinase subunit beta

See identical proteins and their annotated locations for NP_445807.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q9QY78

UniProtKB/TrEMBL

A6IW61, G3V8H5

Related

ENSRNOP00000025851.2, ENSRNOT00000025851.6

Conserved Domains (4) summary

cd14038
Location:20 → 309

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

cd17046
Location:310 → 390

Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins

pfam12179
Location:708 → 742

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

pfam18397
Location:389 → 663

IKBKB_SDD; IQBAL scaffold dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

76021968..76075717

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275786.1 → XP_063131856.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1

UniProtKB/Swiss-Prot

Q9QY78

Related

ENSRNOP00000112638.1, ENSRNOT00000154195.1
XM_063275787.1 → XP_063131857.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2
XM_039094867.2 → XP_038950795.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3

Conserved Domains (2) summary

cd14038
Location:20 → 309

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

cd17046
Location:310 → 390

Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins