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    PYL2 PYR1-like 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817145, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PYL2
    Official Full Name
    PYR1-like 2
    Primary source
    TAIR:AT2G26040
    Locus tag
    AT2G26040
    See related
    Araport:AT2G26040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PYR1-like 2; RCAR14; regulatory components of ABA receptor 14; T19L18.15; T19L18_15
    Summary
    Encodes a member of the PYR (pyrabactin resistance)/PYL(PYR1-like)/RCAR (regulatory components of ABA receptor) family proteins with 14 members. PYR/PYL/RCAR family proteins function as abscisic acid sensors. Mediate ABA-dependent regulation of protein phosphatase 2Cs ABI1 and ABI2.
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    Genomic context

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    See PYL2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (11094258..11095542, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene plant defensin 1.2b Neighboring gene F-box/RNI-like/FBD-like domains-containing protein Neighboring gene hypothetical protein (DUF1644) Neighboring gene Transducin/WD40 repeat-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular basis of the activation and dissociation of dimeric PYL2 receptor in abscisic acid signaling. Zhao C, et al. Phys Chem Chem Phys, 2022 Jan 4. PMID 34935010
    2. ABA Receptor Subfamily III Enhances Abscisic Acid Sensitivity and Improves the Drought Tolerance of Arabidopsis. Li X, et al. Int J Mol Sci, 2018 Jul 2. PMID 30004422, Free PMC Article
    3. Rapid Phosphoproteomic Effects of Abscisic Acid (ABA) on Wild-Type and ABA Receptor-Deficient A. thaliana Mutants. Minkoff BB, et al. Mol Cell Proteomics, 2015 May. PMID 25693798, Free PMC Article
    4. The role of Arabidopsis ABA receptors from the PYR/PYL/RCAR family in stomatal acclimation and closure signal integration. Dittrich M, et al. Nat Plants, 2019 Sep. PMID 31451795
    5. Thermostability of the PYL-PP2C Heterodimer Is Dependent on Magnesium: In Silico Insights into the Link between Heat Stress Response and Magnesium Deficiency in Plants. Timucin E, et al. J Chem Inf Model, 2018 Mar 26. PMID 29437392

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular basis of the activation and dissociation of dimeric PYL2 receptor in abscisic acid signaling.
      Title: Molecular basis of the activation and dissociation of dimeric PYL2 receptor in abscisic acid signaling.
    2. Of the six members of the PYR/PYL/RCAR family expressed in guard cells, PYL2 is sufficient for guard cell abscisc acid-induced responses, whereas in the responses to CO2, PYL4 and PYL5 are essential.
      Title: The role of Arabidopsis ABA receptors from the PYR/PYL/RCAR family in stomatal acclimation and closure signal integration.
    3. Molecular dynamics simulations have been applied to two different PYL2-HAB1 complex heterodimer systems representing normal and magnesium deficient conditions. The heterodimer conformation and stability were delineated at high temperatures mimicking heat stress. Results showed that the thermostability of the heat stress response heterodimer was significantly dependent on the magnesium.
      Title: Thermostability of the PYL-PP2C Heterodimer Is Dependent on Magnesium: In Silico Insights into the Link between Heat Stress Response and Magnesium Deficiency in Plants.
    4. These findings confirm that the subfamily III plays a key role in ABA-mediated developmental processes and, more importantly, is involved in drought tolerance in the ABA-dependent pathway.
      Title: ABA Receptor Subfamily III Enhances Abscisic Acid Sensitivity and Improves the Drought Tolerance of Arabidopsis.
    5. Abscisic acid receptor PYL2 deletion changes the phosphorylation pattern of SnRK2 in response to abscisic acid signaling.
      Title: Rapid Phosphoproteomic Effects of Abscisic Acid (ABA) on Wild-Type and ABA Receptor-Deficient A. thaliana Mutants.
    6. study reports a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors; structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation
      Title: Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.
    7. Subtle changes in the binding pockets of PYR/PYL proteins control ligand orientation inside the pocket, and this is sufficient to explain whether pyrabactin acts as an effective receptor agonist. [PYL2]
      Title: Structural basis for selective activation of ABA receptors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables abscisic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in abscisic acid-activated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within abscisic acid-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in abscisic acid-activated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    PYR1-like 2
    NP_180174.1
    • PYR1-like 2 (PYL2); CONTAINS InterPro DOMAIN/s: Polyketide cyclase/dehydrase (InterPro:IPR019587); BEST Arabidopsis thaliana protein match is: PYR1-like 3 (TAIR:AT1G73000.1); Has 445 Blast hits to 441 proteins in 38 species: Archae - 0; Bacteria - 5; Metazoa - 0; Fungi - 0; Plants - 439; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11094258..11095542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128163.2 → NP_180174.1  PYR1-like 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180174.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80992
      UniProtKB/TrEMBL
      A0A654EW91
      Conserved Domains (1) summary
      cd07821
      Location:35 → 177
      PYR_PYL_RCAR_like; Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80992.1

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