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    CYP5 cyclophilin 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817546, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP5
    Official Full Name
    cyclophilin 5
    Primary source
    TAIR:AT2G29960
    Locus tag
    AT2G29960
    See related
    Araport:AT2G29960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA CYCLOPHILIN 5; ATCYP5; CYCLOPHILIN 19-4; cyclophilin 5; CYP19-4; F23F1.12; F23F1_12
    Summary
    encodes a cyclophilin protein that exhibits peptidylprolyl cis/trans-isomerase and protein refolding activities that were sensitive to cyclosporin A. The protein interacts with GNOM in vitro and is localized to both the cytosolic and membrane fractions. The gene is expressed in the developing embryo.
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    Genomic context

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    See CYP5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (12767610..12770668, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene F-box/RNI-like superfamily protein Neighboring gene pleiotropic drug resistance 3 Neighboring gene ELF4-like 1 Neighboring gene ncRNA Neighboring gene Double Clp-N motif-containing P-loop nucleoside triphosphate hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved domain of the arabidopsis GNOM protein mediates subunit interaction and cyclophilin 5 binding. Grebe M, et al. Plant Cell, 2000 Mar. PMID 10715321, Free PMC Article
    2. Desensitization of GSTF8 induction by a prior chemical treatment is long lasting and operates in a tissue-dependent manner. Foley RC, et al. Plant Physiol, 2006 Sep. PMID 16829588, Free PMC Article
    3. Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains. Anders N, et al. Plant Cell, 2008 Jan. PMID 18203920, Free PMC Article
    4. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
    5. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084509.1
    NM_001336236.1
    NM_128550.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein refolding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    cyclophilin 5
    NP_001077978.1
    • cyclophilin 5 (CYP5); FUNCTIONS IN: peptidyl-prolyl cis-trans isomerase activity; INVOLVED IN: protein folding; LOCATED IN: cytosol, Golgi stack, endoplasmic reticulum, membrane fraction, multivesicular body; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: rotamase CYP 7 (TAIR:AT5G58710.1); Has 15750 Blast hits to 15712 proteins in 2648 species: Archae - 109; Bacteria - 6497; Metazoa - 2918; Fungi - 1356; Plants - 1258; Viruses - 4; Other Eukaryotes - 3608 (source: NCBI BLink).
    NP_001318316.1
    • cyclophilin 5 (CYP5); FUNCTIONS IN: peptidyl-prolyl cis-trans isomerase activity; INVOLVED IN: protein folding; LOCATED IN: cytosol, Golgi stack, endoplasmic reticulum, membrane fraction, multivesicular body; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: rotamase CYP 7 (TAIR:AT5G58710.1); Has 16420 Blast hits to 16390 proteins in 2652 species: Archae - 108; Bacteria - 6810; Metazoa - 2915; Fungi - 1388; Plants - 1273; Viruses - 4; Other Eukaryotes - 3922 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12767610..12770668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336236.1 → NP_001318316.1  cyclophilin 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MS66, O22515, O80876, Q8LDP4
      UniProtKB/TrEMBL
      A0A178VZ96, A0A5S9X2F4, A0A654F2G7
      Conserved Domains (1) summary
      cd01926
      Location:32 → 197
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

    2. NM_128550.4 → NP_180557.1  cyclophilin 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180557.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MS66, O22515, O80876, Q8LDP4
      UniProtKB/TrEMBL
      A0A178VZ96, A0A5S9X2F4, A0A654F2G7
      Conserved Domains (1) summary
      cd01926
      Location:32 → 197
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

    3. NM_001084509.1 → NP_001077978.1  cyclophilin 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077978.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VZ96
      Conserved Domains (1) summary
      cl00197
      Location:32 → 187
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LDP4.2

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