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    TOPP1 type one protein phosphatase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817489, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TOPP1
    Official Full Name
    type one protein phosphatase 1
    Primary source
    TAIR:AT2G29400
    Locus tag
    AT2G29400
    See related
    Araport:AT2G29400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PP1-AT; PROTEIN PHOSPHATASE 1; type one protein phosphatase 1
    Summary
    Type 1 protein phosphatase, expressed in roots, rosettes and flowers
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    Genomic context

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    See TOPP1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (12613014..12615414, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene highly ABA-induced PP2C protein 3 Neighboring gene sterol 4-alpha-methyl-oxidase 2-2 Neighboring gene metal tolerance protein B1 Neighboring gene ncRNA Neighboring gene glutathione S-transferase tau 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complementation of the cs dis2-11 cell cycle mutant of Schizosaccharomyces pombe by a protein phosphatase from Arabidopsis thaliana. Nitschke K, et al. EMBO J, 1992 Apr. PMID 1314161, Free PMC Article
    2. Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling. Hou YJ, et al. PLoS Genet, 2016 Mar. PMID 26943172, Free PMC Article
    3. Expression of multiple type 1 phosphoprotein phosphatases in Arabidopsis thaliana. Smith RD, et al. Plant Mol Biol, 1993 Jan. PMID 7678768
    4. Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit. Templeton GW, et al. Biochem J, 2011 Apr 1. PMID 21222654
    5. Identification and functional characterization of inhibitor-3, a regulatory subunit of protein phosphatase 1 in plants. Takemiya A, et al. Plant Physiol, 2009 May. PMID 19329567, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taken together, our results uncover TOPP1 and AtI-2 as negative regulators of ABA signaling.
      Title: Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_128494.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein dephosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    part_of protein phosphatase type 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type one protein phosphatase 1
    NP_180501.1
    • type one protein phosphatase 1 (TOPP1); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: type one serine/threonine protein phosphatase 2 (TAIR:AT5G59160.3); Has 7268 Blast hits to 7072 proteins in 663 species: Archae - 78; Bacteria - 610; Metazoa - 2414; Fungi - 1413; Plants - 987; Viruses - 22; Other Eukaryotes - 1744 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12613014..12615414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128494.5 → NP_180501.1  type one protein phosphatase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180501.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30366
      UniProtKB/TrEMBL
      A0A178VXL8, A0A5S9X295
      Conserved Domains (1) summary
      cd07414
      Location:19 → 310
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30366.1

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