Zfp3 zinc finger protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp3provided by MGI
Official Full Name: zinc finger protein 3provided by MGI
Primary source: MGI:MGI:99177
See related: Ensembl:ENSMUSG00000043602 AllianceGenome:MGI:99177
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fnp-1; Zfp-3; B230309J24
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in central nervous system and genitourinary system. Orthologous to human ZFP3 (ZFP3 zinc finger protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 3.0), cerebellum adult (RPKM 2.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 43.21 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70655273..70663754)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70764447..70772928)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AI854635 is a novel exercise-related gene involved in myoblast differentiation
Title: Exercise-related novel gene is involved in myoblast differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177565.3 → NP_808233.1 zinc finger protein 3

See identical proteins and their annotated locations for NP_808233.1

Status: VALIDATED

Source sequence(s)

AI854635, AK045753

Consensus CDS

CCDS24966.1

UniProtKB/Swiss-Prot

Q8BLB0

Related

ENSMUSP00000054020.6, ENSMUST00000060444.6

Conserved Domains (4) summary

COG5048
Location:134 → 494

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:166 → 186

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:136 → 158

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:374 → 399

zf-H2C2_2; Zinc-finger double domain