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    Kcnt1 potassium channel, subfamily T, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 227632, updated on 27-Dec-2024

    Summary

    Official Symbol
    Kcnt1provided by MGI
    Official Full Name
    potassium channel, subfamily T, member 1provided by MGI
    Primary source
    MGI:MGI:1924627
    See related
    Ensembl:ENSMUSG00000058740 AllianceGenome:MGI:1924627
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    slo2; Slack; Slo2.2; C030030G16Rik
    Summary
    This gene encodes a member of the Slo potassium channel family that has shown to be activated by both sodium and chloride ions. This channel represents the largest potassium channel subunit yet identified. This channel may be important in development and pain signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Biased expression in cerebellum adult (RPKM 46.3), frontal lobe adult (RPKM 20.5) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kcnt1 in Genome Data Viewer
    Location:
    2 A3; 2 18.27 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25753807..25808285)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25863791..25918273)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene lipocalin 9 Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 1 Neighboring gene STARR-seq mESC enhancer starr_03968 Neighboring gene calmodulin regulated spectrin-associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1002 Neighboring gene ubiquitin associated domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3363

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • mKiaa1422

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables intracellular sodium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables outward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane potential IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    potassium channel subfamily T member 1
    Names
    potassium channel subunit homolog
    sodium-activated potassium channel

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145403.3NP_001138875.1  potassium channel subfamily T member 1 isoform 2

      See identical proteins and their annotated locations for NP_001138875.1

      Status: VALIDATED

      Source sequence(s)
      AL731682
      Consensus CDS
      CCDS50537.1
      UniProtKB/TrEMBL
      A0A0G2JG99, C0KTP6
      Related
      ENSMUSP00000132212.2, ENSMUST00000171268.8
      Conserved Domains (3) summary
      pfam00520
      Location:123303
      Ion_trans; Ion transport protein
      pfam03493
      Location:465559
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:239311
      Ion_trans_2; Ion channel
    2. NM_001302351.2NP_001289280.1  potassium channel subfamily T member 1 isoform 3

      See identical proteins and their annotated locations for NP_001289280.1

      Status: VALIDATED

      Source sequence(s)
      AL731682
      Consensus CDS
      CCDS79757.1
      UniProtKB/Swiss-Prot
      B2RUK3, Q6ZPR4, Q8C3E7
      UniProtKB/TrEMBL
      A0A0G2JG99
      Related
      ENSMUSP00000109809.3, ENSMUST00000114172.6
      Conserved Domains (2) summary
      pfam03493
      Location:470565
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:244317
      Ion_trans_2; Ion channel
    3. NM_175462.5NP_780671.2  potassium channel subfamily T member 1 isoform 1

      See identical proteins and their annotated locations for NP_780671.2

      Status: VALIDATED

      Source sequence(s)
      AL731682
      Consensus CDS
      CCDS15794.1
      UniProtKB/TrEMBL
      A0A0G2JG99, A2AHB8
      Related
      ENSMUSP00000039058.7, ENSMUST00000037580.13
      Conserved Domains (2) summary
      pfam03493
      Location:484579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:258331
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25753807..25808285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160711.1XP_036016604.1  potassium channel subfamily T member 1 isoform X24

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (2) summary
      pfam03493
      Location:231333
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:1284
      Ion_trans_2; Ion channel
    2. XM_036160715.1XP_036016608.1  potassium channel subfamily T member 1 isoform X26

      Conserved Domains (1) summary
      pfam03493
      Location:50152
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    3. XM_036160708.1XP_036016601.1  potassium channel subfamily T member 1 isoform X22

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:9169
      Ion_trans; Ion transport protein
      pfam03493
      Location:323425
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:105177
      Ion_trans_2; Ion channel
    4. XM_036160716.1XP_036016609.1  potassium channel subfamily T member 1 isoform X27

      Conserved Domains (1) summary
      pfam03493
      Location:54111
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    5. XM_006497892.5XP_006497955.1  potassium channel subfamily T member 1 isoform X23

      UniProtKB/TrEMBL
      A0A0G2JER3, A0A0G2JG99
      Related
      ENSMUSP00000142870.2, ENSMUST00000198204.5
      Conserved Domains (3) summary
      pfam00520
      Location:123289
      Ion_trans; Ion transport protein
      pfam03493
      Location:450545
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:225291
      Ion_trans_2; Ion channel
    6. XM_006497891.5XP_006497954.1  potassium channel subfamily T member 1 isoform X18

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:123289
      Ion_trans; Ion transport protein
      pfam03493
      Location:451546
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:225291
      Ion_trans_2; Ion channel
    7. XM_030249674.2XP_030105534.1  potassium channel subfamily T member 1 isoform X19

      UniProtKB/TrEMBL
      A0A0G2JG99
      Related
      ENSMUSP00000143482.2, ENSMUST00000200434.5
      Conserved Domains (3) summary
      pfam00520
      Location:123289
      Ion_trans; Ion transport protein
      pfam03493
      Location:450545
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:225291
      Ion_trans_2; Ion channel
    8. XM_030249691.1XP_030105551.1  potassium channel subfamily T member 1 isoform X26

      Conserved Domains (1) summary
      pfam03493
      Location:50152
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    9. XM_036160720.1XP_036016613.1  potassium channel subfamily T member 1 isoform X31

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:63270
      Ion_trans; Ion transport protein
      pfam03493
      Location:424526
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:206278
      Ion_trans_2; Ion channel
    10. XM_006497895.5XP_006497958.2  potassium channel subfamily T member 1 isoform X25

      Conserved Domains (3) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam03493
      Location:485580
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    11. XM_030249677.2XP_030105537.1  potassium channel subfamily T member 1 isoform X21

      Conserved Domains (3) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam03493
      Location:485580
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    12. XM_006497883.5XP_006497946.2  potassium channel subfamily T member 1 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam03493
      Location:485580
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    13. XM_006497884.5XP_006497947.2  potassium channel subfamily T member 1 isoform X11

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam03493
      Location:485580
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    14. XM_017317198.3XP_017172687.1  potassium channel subfamily T member 1 isoform X16

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (2) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    15. XM_017317195.3XP_017172684.1  potassium channel subfamily T member 1 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam03493
      Location:484579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    16. XM_006497889.5XP_006497952.2  potassium channel subfamily T member 1 isoform X20

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (2) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    17. XM_017317197.2XP_017172686.1  potassium channel subfamily T member 1 isoform X15

      UniProtKB/TrEMBL
      A0A0G2JG99, A2AHB7
      Related
      ENSMUSP00000109813.3, ENSMUST00000114176.9
      Conserved Domains (3) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam03493
      Location:484579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    18. XM_006497886.4XP_006497949.2  potassium channel subfamily T member 1 isoform X13

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      PRK10537
      Location:158288
      PRK10537; voltage-gated potassium channel protein
      pfam03493
      Location:457552
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:231297
      Ion_trans_2; Ion channel
    19. XM_006497877.4XP_006497940.2  potassium channel subfamily T member 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam03493
      Location:485580
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    20. XM_006497879.5XP_006497942.2  potassium channel subfamily T member 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam03493
      Location:485580
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    21. XM_036160686.1XP_036016579.1  potassium channel subfamily T member 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:143323
      Ion_trans; Ion transport protein
      pfam03493
      Location:477579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:259331
      Ion_trans_2; Ion channel
    22. XM_036160690.1XP_036016583.1  potassium channel subfamily T member 1 isoform X14

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      PRK10537
      Location:158288
      PRK10537; voltage-gated potassium channel protein
      pfam03493
      Location:449551
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:231303
      Ion_trans_2; Ion channel
    23. XM_030249663.2XP_030105523.1  potassium channel subfamily T member 1 isoform X17

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (2) summary
      pfam00520
      Location:143309
      Ion_trans; Ion transport protein
      pfam07885
      Location:245311
      Ion_trans_2; Ion channel
    24. XM_006497880.4XP_006497943.2  potassium channel subfamily T member 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam03493
      Location:485580
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    25. XM_006497878.4XP_006497941.2  potassium channel subfamily T member 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam03493
      Location:484579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    26. XM_006497881.4XP_006497944.2  potassium channel subfamily T member 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JG99, A2AHB9
      Related
      ENSMUSP00000143106.2, ENSMUST00000197917.5
      Conserved Domains (3) summary
      pfam00520
      Location:157323
      Ion_trans; Ion transport protein
      pfam03493
      Location:484579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:259325
      Ion_trans_2; Ion channel
    27. XM_006497882.5XP_006497945.2  potassium channel subfamily T member 1 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:143309
      Ion_trans; Ion transport protein
      pfam03493
      Location:471566
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:245311
      Ion_trans_2; Ion channel
    28. XM_030249645.1XP_030105505.1  potassium channel subfamily T member 1 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:143309
      Ion_trans; Ion transport protein
      pfam03493
      Location:470565
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:245311
      Ion_trans_2; Ion channel
    29. XM_030249649.1XP_030105509.1  potassium channel subfamily T member 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2JG99
      Conserved Domains (3) summary
      pfam00520
      Location:143309
      Ion_trans; Ion transport protein
      pfam03493
      Location:470565
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:245311
      Ion_trans_2; Ion channel
    30. XM_036160719.1XP_036016612.1  potassium channel subfamily T member 1 isoform X29

      Conserved Domains (1) summary
      pfam03493
      Location:183
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    31. XM_006497896.4XP_006497959.1  potassium channel subfamily T member 1 isoform X27

      Conserved Domains (1) summary
      pfam03493
      Location:54111
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    32. XM_030249700.1XP_030105560.1  potassium channel subfamily T member 1 isoform X28

      Conserved Domains (1) summary
      pfam03493
      Location:54111
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    33. XM_036160718.1XP_036016611.1  potassium channel subfamily T member 1 isoform X27

      Conserved Domains (1) summary
      pfam03493
      Location:54111
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    34. XM_017317210.2XP_017172699.1  potassium channel subfamily T member 1 isoform X30

      Conserved Domains (1) summary
      cl29357
      Location:933
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    RNA

    1. XR_004939568.1 RNA Sequence

    2. XR_003952108.2 RNA Sequence

    3. XR_004939562.1 RNA Sequence

    4. XR_004939563.1 RNA Sequence