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    AOR Oxidoreductase, zinc-binding dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838984, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AOR
    Official Full Name
    Oxidoreductase, zinc-binding dehydrogenase family protein
    Primary source
    TAIR:AT1G23740
    Locus tag
    AT1G23740
    See related
    Araport:AT1G23740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    alkenal/one oxidoreductase; F5O8.29; F5O8_29
    Summary
    AOR is an alkenal/one oxidoreductase that acts on compounds with unsaturated alpha,beta-carbonyls. The activity of this enzyme with a number of substrates, including acrolein and 3-buten-2-one, was demonstrated in vitro using a truncated form of the protein that lacked approximately 80 of the first amino acids. This protein appears to localize to the chloroplast where it likely helps to maintain the photosynthetic process by detoxifying reactive carbonyls formed during lipid peroxidation.
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    Genomic context

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    See AOR in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (8398115..8399836, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Proline-rich extensin-like family protein Neighboring gene beta carbonic anhydrase 3 Neighboring gene Nucleic acid-binding, OB-fold-like protein Neighboring gene BURP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of Chloroplastic Alkenal/One Oxidoreductase Represses the Carbon Catabolic Pathway in Arabidopsis Leaves during Night. Takagi D, et al. Plant Physiol, 2016 Apr. PMID 26884484, Free PMC Article
    2. Chloroplastic NADPH-dependent alkenal/one oxidoreductase contributes to the detoxification of reactive carbonyls produced under oxidative stress. Yamauchi Y, et al. FEBS Lett, 2012 Apr 24. PMID 22575657
    3. NADPH-dependent reductases involved in the detoxification of reactive carbonyls in plants. Yamauchi Y, et al. J Biol Chem, 2011 Mar 4. PMID 21169366, Free PMC Article
    4. The chloroplast lumen and stromal proteomes of Arabidopsis thaliana show differential sensitivity to short- and long-term exposure to low temperature. Goulas E, et al. Plant J, 2006 Sep. PMID 16923014
    5. High light response of the thylakoid proteome in arabidopsis wild type and the ascorbate-deficient mutant vtc2-2. A comparative proteomics study. Giacomelli L, et al. Plant Physiol, 2006 Jun. PMID 16648217, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the detoxification of lipid-derived reactive carbonyl species by AtAOR in chloroplasts contributes to the protection of dark respiration and supports plant growth during the night.
      Title: Suppression of Chloroplastic Alkenal/One Oxidoreductase Represses the Carbon Catabolic Pathway in Arabidopsis Leaves during Night.
    2. NADPH-dependent alkenal/one oxidoreductase (AOR) can contribute to detoxify stromal RCs produced under oxidative stress.[AOR]
      Title: Chloroplastic NADPH-dependent alkenal/one oxidoreductase contributes to the detoxification of reactive carbonyls produced under oxidative stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_102222.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2-alkenal reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enone reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in stromule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in thylakoid HDA PubMed 

    General protein information

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    Preferred Names
    Oxidoreductase, zinc-binding dehydrogenase family protein
    NP_173786.1
    • Oxidoreductase, zinc-binding dehydrogenase family protein; FUNCTIONS IN: oxidoreductase activity, zinc ion binding; INVOLVED IN: response to cold; LOCATED IN: in 6 components; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: GroES-like (InterPro:IPR011032), Alcohol dehydrogenase GroES-like (InterPro:IPR013154), Quinone oxidoreductase/zeta-crystallin, conserved site (InterPro:IPR002364), Alcohol dehydrogenase, C-terminal (InterPro:IPR013149), Alcohol dehydrogenase superfamily, zinc-containing (InterPro:IPR002085); BEST Arabidopsis thaliana protein match is: Oxidoreductase, zinc-binding dehydrogenase family protein (TAIR:AT4G13010.1); Has 40144 Blast hits to 39997 proteins in 2741 species: Archae - 622; Bacteria - 25898; Metazoa - 1494; Fungi - 3833; Plants - 1284; Viruses - 3; Other Eukaryotes - 7010 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8398115..8399836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102222.5 → NP_173786.1  Oxidoreductase, zinc-binding dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173786.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q945P3, Q9ZUC1
      UniProtKB/TrEMBL
      A0A5S9VPF3, A0A654ECJ1
      Conserved Domains (1) summary
      cd05289
      Location:78 → 382
      MDR_like_2; alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZUC1.2

    Gene LinkOut

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