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    GLR2 glutamate receptor 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816231, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLR2
    Official Full Name
    glutamate receptor 2
    Primary source
    TAIR:AT2G17260
    Locus tag
    AT2G17260
    See related
    Araport:AT2G17260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGLR2; ATGLR3.1; F5J6.2; F5J6_2; GLR3.1; glutamate receptor 2; GLUTAMATE RECEPTOR 2
    Summary
    Encodes a glutamate receptor. Involved in calcium-programmed stomatal closure.
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    Genomic context

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    See GLR2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (7504748..7508394)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene arginine/serine-rich-like splicing factor Neighboring gene CCAAT-binding factor Neighboring gene homoserine kinase Neighboring gene phosphate transporter 3;3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De-regulated expression of the plant glutamate receptor homolog AtGLR3.1 impairs long-term Ca2+-programmed stomatal closure. Cho D, et al. Plant J, 2009 May. PMID 19143998
    2. L-Met Activates Arabidopsis GLR Ca(2+) Channels Upstream of ROS Production and Regulates Stomatal Movement. Kong D, et al. Cell Rep, 2016 Dec 6. PMID 27926860
    3. Computational analysis of the glutamate receptor gene family of Arabidopsis thaliana. Roy BC, et al. J Biomol Struct Dyn, 2017 Aug. PMID 27632363
    4. Glutamate-receptor genes in plants. Lam HM, et al. Nature, 1998 Nov 12. PMID 9823891
    5. Inter-subunit interactions between glutamate-like receptors in Arabidopsis. Price MB, et al. Plant Signal Behav, 2013. PMID 24300102, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In AT2G17260 and AT4G35290, presence of RAV1-A binding site motif in the promoter coupled with results from gene ontology annotation indicate their role in stomatal movement through abscisic acid signaling.
      Title: Computational analysis of the glutamate receptor gene family of Arabidopsis thaliana.
    2. Our data indicate that GLR3.1/3.5 constitute L-Met-activated Ca(2+) channels responsible for maintaining basal [Ca(2+)]cyt, play a pivotal role in plant growth, and act upstream of ROS, thereby regulating stomatal aperture
      Title: L-Met Activates Arabidopsis GLR Ca(2+) Channels Upstream of ROS Production and Regulates Stomatal Movement.
    3. Over-expression of GLR3.1 led to impairment in external Ca2+-induced stomatal closure.
      Title: De-regulated expression of the plant glutamate receptor homolog AtGLR3.1 impairs long-term Ca2+-programmed stomatal closure.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001335544.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables intracellularly ligand-gated monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to amino acid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor 2
    NP_001318239.1
    • glutamate receptor 2 (GLR2); FUNCTIONS IN: intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus, stomatal movement; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Glutamate receptor-related (InterPro:IPR015683), Extracellular ligand-binding receptor (InterPro:IPR001828), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 2 (TAIR:AT4G35290.1); Has 6275 Blast hits to 6137 proteins in 506 species: Archae - 28; Bacteria - 848; Metazoa - 4591; Fungi - 0; Plants - 633; Viruses - 0; Other Eukaryotes - 175 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7504748..7508394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335544.1 → NP_001318239.1  glutamate receptor 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IMH4, O49119, Q6RKN5, Q7XJL2, Q9ZT36
      UniProtKB/TrEMBL
      A0A178VW54
      Conserved Domains (3) summary
      cd06366
      Location:35 → 424
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      cd13686
      Location:468 → 808
      GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold
      pfam00060
      Location:594 → 843
      Lig_chan; Ligand-gated ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7XJL2.3

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