APR2 5'adenylylphosphosulfate reductase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: APR2
Official Full Name: 5'adenylylphosphosulfate reductase 2
Primary source: TAIR:AT1G62180
Locus tag: AT1G62180
See related: Araport:AT1G62180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 3'-PHOSPHOADENOSINE-5'-PHOSPHOSULFATE (PAPS) REDUCTASE HOMOLOG 43; 5'adenylylphosphosulfate reductase 2; ADENOSINE-5'-PHOSPHOSULFATE REDUCTASE; APS REDUCTASE; APSR; ATAPR2; F19K23.11; F19K23_11; PRH; PRH43
Summary: encodes a adenosine 5'-phosphosulfate reductase, involved in sulfate assimilation. Is a major effect locus for natural variation of shoot sulfate content in Arabidopsis.
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Genomic context

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See APR2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 4

Sequence:: Chromosome: 1; NC_003070.9 (22975530..22977885, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The frequency of APR2 alleles in the global Arabidopsis population.Variation in sulfur and selenium accumulation is controlled by naturally occurring isoforms of APR2.
Title: Variation in sulfur and selenium accumulation is controlled by naturally occurring isoforms of the key sulfur assimilation enzyme ADENOSINE 5'-PHOSPHOSULFATE REDUCTASE2 across the Arabidopsis species range.
HY5 plays an important role in regulation of APR1 and APR2 gene expression and plant sulfate assimilation
Title: The key enzyme of sulfate assimilation, adenosine 5'-phosphosulfate reductase, is regulated by HY5 in Arabidopsis.
A mutant Arabidopsis line (apr2-1) was studied to determine whether APR2 has a role in selenium tolerance and metabolism.
Title: Adenosine 5'-phosphosulfate reductase (APR2) mutation in Arabidopsis implicates glutathione deficiency in selenate toxicity.
APR2 is a key enzyme of the assimilatory sulfate reduction pathway responsible for a decrease in enzyme activity, leading to sulfate accumulation in the plant.
Title: Natural variation for sulfate content in Arabidopsis thaliana is highly controlled by APR2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001198364.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables adenylyl-sulfate reductase (glutathione) activity	IEA Inferred from Electronic Annotation more info
enables adenylyl-sulfate reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoadenylyl-sulfate reductase (thioredoxin) activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoadenylyl-sulfate reductase (thioredoxin) activity	IEA Inferred from Electronic Annotation more info
enables phosphoadenylyl-sulfate reductase (thioredoxin) activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within sulfate assimilation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sulfate assimilation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	IDA Inferred from Direct Assay more info	PubMed
NOT located_in chloroplast thylakoid	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 5'adenylylphosphosulfate reductase 2

NP_001185293.1

5'adenylylphosphosulfate reductase 2 (APR2); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Thioredoxin-independent 5'-adenylylsulphate reductase (InterPro:IPR004508), Thioredoxin fold (InterPro:IPR012335), Phosphoadenosine phosphosulphate reductase (InterPro:IPR002500), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336), Thioredoxin domain (InterPro:IPR013766); BEST Arabidopsis thaliana protein match is: APS reductase 3 (TAIR:AT4G21990.1).

NP_176409.1

5'adenylylphosphosulfate reductase 2 (APR2); FUNCTIONS IN: adenylyl-sulfate reductase activity, phosphoadenylyl-sulfate reductase (thioredoxin) activity; INVOLVED IN: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin), sulfate assimilation; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Thioredoxin-independent 5'-adenylylsulphate reductase (InterPro:IPR004508), Thioredoxin fold (InterPro:IPR012335), Phosphoadenosine phosphosulphate reductase (InterPro:IPR002500), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: APS reductase 3 (TAIR:AT4G21990.1); Has 5381 Blast hits to 4904 proteins in 1602 species: Archae - 157; Bacteria - 2618; Metazoa - 1060; Fungi - 451; Plants - 490; Viruses - 0; Other Eukaryotes - 605 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

22975530..22977885 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104899.3 → NP_176409.1 5'adenylylphosphosulfate reductase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176409.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O04215, O04583, O22554, P92981, Q38947, Q541D4

UniProtKB/TrEMBL

A0A5S9WRW1, A0A654ELQ9

Conserved Domains (1) summary

TIGR00424
Location:1 → 454

APS_reduc; 5'-adenylylsulfate reductase, thioredoxin-independent
NM_001198364.1 → NP_001185293.1 5'adenylylphosphosulfate reductase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001185293.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9WRW1, A0A654ELQ9, F4HX50

Conserved Domains (3) summary

PRK02090
Location:76 → 315

PRK02090; phosphoadenosine phosphosulfate reductase; Provisional

cd02993
Location:336 → 443

PDI_a_APS_reductase; PDIa family, 5'-Adenylylsulfate (APS) reductase subfamily; composed of plant-type APS reductases containing a C-terminal redox active TRX domain and an N-terminal reductase domain which is part of a superfamily that includes N type ATP PPases. APS ...

TIGR00424
Location:1 → 447

APS_reduc; 5'-adenylylsulfate reductase, thioredoxin-independent