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    GLX1 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837731, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLX1
    Official Full Name
    glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein
    Primary source
    TAIR:AT1G11840
    Locus tag
    AT1G11840
    See related
    Araport:AT1G11840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGLX1; F12F1.32; F12F1_32; GLYOXALASE I; glyoxalase I homolog
    Summary
    Encodes a glyoxalase I homolog ATGLX1.
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    Genomic context

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    See GLX1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (3995158..3997965)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene O-Glycosyl hydrolases family 17 protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Glycine cleavage T-protein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methylglyoxal induces inhibition of growth, accumulation of anthocyanin, and activation of glyoxalase I and II in Arabidopsis thaliana. Hoque TS, et al. J Biochem Mol Toxicol, 2017 Jul. PMID 28117932
    2. Arabidopsis thaliana Contains Both Ni2+ and Zn2+ Dependent Glyoxalase I Enzymes and Ectopic Expression of the Latter Contributes More towards Abiotic Stress Tolerance in E. coli. Jain M, et al. PLoS One, 2016. PMID 27415831, Free PMC Article
    3. In vivo subcellular targeting analysis validates a novel peroxisome targeting signal type 2 and the peroxisomal localization of two proteins with putative functions in defense in Arabidopsis. Quan S, et al. Plant Signal Behav, 2010 Feb. PMID 20009535, Free PMC Article
    4. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931
    5. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001035948.1
    NM_001035949.3
    NM_001198039.1
    NM_101055.4
    NM_179312.4
    NM_179313.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables lactoylglutathione lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein
    NP_001031025.1
    • glyoxalase I homolog (GLX1); FUNCTIONS IN: lactoylglutathione lyase activity, metal ion binding; INVOLVED IN: response to cadmium ion, carbohydrate metabolic process; LOCATED IN: peroxisome, plasma membrane, vacuole; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glyoxalase I (InterPro:IPR004361), Glyoxalase I, conserved site (InterPro:IPR018146), Glyoxalase/bleomycin resistance protein/dioxygenase (InterPro:IPR004360); BEST Arabidopsis thaliana protein match is: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein (TAIR:AT1G67280.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001031026.1
    • glyoxalase I homolog (GLX1); FUNCTIONS IN: lactoylglutathione lyase activity, metal ion binding; INVOLVED IN: response to cadmium ion, carbohydrate metabolic process; LOCATED IN: peroxisome, plasma membrane, vacuole; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glyoxalase I (InterPro:IPR004361), Glyoxalase I, conserved site (InterPro:IPR018146), Glyoxalase/bleomycin resistance protein/dioxygenase (InterPro:IPR004360); BEST Arabidopsis thaliana protein match is: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein (TAIR:AT1G67280.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001184968.1
    • glyoxalase I homolog (GLX1); FUNCTIONS IN: lactoylglutathione lyase activity, metal ion binding; INVOLVED IN: carbohydrate metabolic process; LOCATED IN: peroxisome; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glyoxalase I (InterPro:IPR004361), Glyoxalase I, conserved site (InterPro:IPR018146), Glyoxalase/bleomycin resistance protein/dioxygenase (InterPro:IPR004360); BEST Arabidopsis thaliana protein match is: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein (TAIR:AT1G67280.1).
    NP_172648.1
    • glyoxalase I homolog (GLX1); FUNCTIONS IN: lactoylglutathione lyase activity, metal ion binding; INVOLVED IN: response to cadmium ion, carbohydrate metabolic process; LOCATED IN: peroxisome, plasma membrane, vacuole, chloroplast envelope; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glyoxalase I (InterPro:IPR004361), Glyoxalase I, conserved site (InterPro:IPR018146), Glyoxalase/bleomycin resistance protein/dioxygenase (InterPro:IPR004360); BEST Arabidopsis thaliana protein match is: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein (TAIR:AT1G67280.1); Has 8678 Blast hits to 5178 proteins in 1682 species: Archae - 141; Bacteria - 5669; Metazoa - 503; Fungi - 263; Plants - 249; Viruses - 0; Other Eukaryotes - 1853 (source: NCBI BLink).
    NP_849643.1
    • glyoxalase I homolog (GLX1); FUNCTIONS IN: lactoylglutathione lyase activity, metal ion binding; INVOLVED IN: response to cadmium ion, carbohydrate metabolic process; LOCATED IN: peroxisome, plasma membrane, vacuole, chloroplast envelope; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glyoxalase I (InterPro:IPR004361), Glyoxalase I, conserved site (InterPro:IPR018146), Glyoxalase/bleomycin resistance protein/dioxygenase (InterPro:IPR004360); BEST Arabidopsis thaliana protein match is: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein (TAIR:AT1G67280.1); Has 8678 Blast hits to 5178 proteins in 1682 species: Archae - 141; Bacteria - 5669; Metazoa - 503; Fungi - 263; Plants - 249; Viruses - 0; Other Eukaryotes - 1853 (source: NCBI BLink).
    NP_849644.2
    • glyoxalase I homolog (GLX1); FUNCTIONS IN: lactoylglutathione lyase activity, metal ion binding; INVOLVED IN: response to cadmium ion, carbohydrate metabolic process; LOCATED IN: peroxisome, plasma membrane, vacuole, chloroplast envelope; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glyoxalase I (InterPro:IPR004361), Glyoxalase I, conserved site (InterPro:IPR018146), Glyoxalase/bleomycin resistance protein/dioxygenase (InterPro:IPR004360); BEST Arabidopsis thaliana protein match is: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein (TAIR:AT1G67280.1); Has 8678 Blast hits to 5178 proteins in 1682 species: Archae - 141; Bacteria - 5669; Metazoa - 503; Fungi - 263; Plants - 249; Viruses - 0; Other Eukaryotes - 1853 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3995158..3997965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101055.4 → NP_172648.1  glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172648.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFN6, B9DGT0, F4IAH9, O65398, Q3EDE2, Q940A4
      UniProtKB/TrEMBL
      A0A178W7B0, A0A5S9TYK7, A0A654E946
      Conserved Domains (1) summary
      PLN02300
      Location:1 → 283
      PLN02300; lactoylglutathione lyase

    2. NM_179312.4 → NP_849643.1  glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849643.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFN6, B9DGT0, F4IAH9, O65398, Q3EDE2, Q940A4
      UniProtKB/TrEMBL
      A0A178W7B0, A0A5S9TYK7, A0A654E946
      Conserved Domains (1) summary
      PLN02300
      Location:1 → 283
      PLN02300; lactoylglutathione lyase

    3. NM_001035949.3 → NP_001031026.1  glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031026.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65398
      Conserved Domains (2) summary
      TIGR00068
      Location:1 → 150
      glyox_I; lactoylglutathione lyase
      cl14632
      Location:150 → 217
      Glo_EDI_BRP_like; This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins

    4. NM_001198039.1 → NP_001184968.1  glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184968.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9TYK7, A0A654E946
      Conserved Domains (3) summary
      PLN02300
      Location:40 → 322
      PLN02300; lactoylglutathione lyase
      TIGR00068
      Location:40 → 189
      glyox_I; lactoylglutathione lyase
      cl14632
      Location:189 → 316
      Glo_EDI_BRP_like; This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins

    5. NM_179313.2 → NP_849644.2  glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849644.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFN6, B9DGT0, F4IAH9, O65398, Q3EDE2, Q940A4
      UniProtKB/TrEMBL
      A0A178W7B0, A0A5S9TYK7, A0A654E946
      Conserved Domains (1) summary
      PLN02300
      Location:1 → 283
      PLN02300; lactoylglutathione lyase

    6. NM_001035948.1 → NP_001031025.1  glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031025.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFN6, B9DGT0, F4IAH9, O65398, Q3EDE2, Q940A4
      UniProtKB/TrEMBL
      A0A178W7B0, A0A5S9TYK7, A0A654E946
      Conserved Domains (1) summary
      PLN02300
      Location:1 → 283
      PLN02300; lactoylglutathione lyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65398.1

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