Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc7a11provided by MGI
Official Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11provided by MGI
Primary source: MGI:MGI:1347355
See related: Ensembl:ENSMUSG00000027737 AllianceGenome:MGI:1347355
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sut; xCT; 9930009M05Rik
Summary: Predicted to enable L-kynurenine transmembrane transporter activity and cystine:glutamate antiporter activity. Involved in L-cystine transport. Acts upstream of or within several processes, including oligopeptide transmembrane transport; regulation of amino acid metabolic process; and regulation of protein localization. Located in apical part of cell; astrocyte projection; and brush border membrane. Is expressed in brain; eye; olfactory epithelium; and spinal cord meninges. Used to study Hermansky-Pudlak syndrome and platelet storage pool deficiency. Orthologous to human SLC7A11 (solute carrier family 7 member 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 13.5), subcutaneous fat pad adult (RPKM 12.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 C; 3 21.72 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (50319385..50403947, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (50364936..50499087, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P62-autophagic pathway degrades SLC7A11 to regulate ferroptosis in doxorubicin-induced cardiotoxicity.
Title: P62-autophagic pathway degrades SLC7A11 to regulate ferroptosis in doxorubicin-induced cardiotoxicity.
Implication of system xc[-] in neuroinflammation during the onset and maintenance of neuropathic pain.
Title: Implication of system x(c)(-) in neuroinflammation during the onset and maintenance of neuropathic pain.
Aberrant Expression of SLC7A11 Impairs the Antimicrobial Activities of Macrophages in Staphylococcus Aureus Osteomyelitis in Mice.
Title: Aberrant Expression of SLC7A11 Impairs the Antimicrobial Activities of Macrophages in Staphylococcus Aureus Osteomyelitis in Mice.
LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis.
Title: LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis.
SLC7A11-ROS/alphaKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression.
Title: SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression.
Compartmentalized role of xCT in supporting pancreatic tumor growth, inflammation and mood disturbance in mice.
Title: Compartmentalized role of xCT in supporting pancreatic tumor growth, inflammation and mood disturbance in mice.
Establishment of SLC7A11-knockout mouse and its preliminary investigation in melanoma.
Title: Establishment of SLC7A11-knockout mouse and its preliminary investigation in melanoma.
IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11.
Title: IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11.
Merlin/NF2 regulates SLC7A11/xCT expression and cell viability under glucose deprivation at high cell density in glioblastoma cells.
Title: Merlin/NF2 regulates SLC7A11/xCT expression and cell viability under glucose deprivation at high cell density in glioblastoma cells.
LINC00942 inhibits ferroptosis and induces the immunosuppression of regulatory T cells by recruiting IGF2BP3/SLC7A11 in hepatocellular carcinoma.
Title: LINC00942 inhibits ferroptosis and induces the immunosuppression of regulatory T cells by recruiting IGF2BP3/SLC7A11 in hepatocellular carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (98)

Phenotypes

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Associated conditions

Description	Tests
subtle gray GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5)
Spontaneous (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

26.MMHAP20FRA11.seq (e-PCR)
- UniSTS:123726

px-45f3 (e-PCR)
- UniSTS:258415

BB453999 (e-PCR)
- UniSTS:207482

px-72g5 (e-PCR)
- UniSTS:258181

AI451155 (e-PCR)
- UniSTS:159111

44.MMHAP7FLG5.seq (e-PCR)
- UniSTS:124552

PMC86714P2 (e-PCR)
- UniSTS:273550

NoName (e-PCR)
- UniSTS:234670

px-24g4 (e-PCR)
- UniSTS:257458

Slc7a11 (e-PCR), detects polymorphism
- UniSTS:546024

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-kynurenine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-kynurenine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables cystine:glutamate antiporter activity	ISO Inferred from Sequence Orthology more info
enables cystine:glutamate antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-cystine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-cystine transport	ISO Inferred from Sequence Orthology more info
involved_in L-cystine transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within L-glutamate import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-kynurenine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-kynurenine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adult behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dipeptide import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glutathione metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glutathione transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular glutamate homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular glutamate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lens fiber cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within limb development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ferroptosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ferroptosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of AMPA glutamate receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cysteine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of glutamate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of glutathione biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of melanin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neutrophil apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to redox state	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striatum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cystine/glutamate transporter

Names: amino acid transport system xc-; cysteine/glutamate transporter; sodium independent anionic amino acid transport system; solute carrier family 7 member 11; subtle gray protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011990.2 → NP_036120.1 cystine/glutamate transporter

See identical proteins and their annotated locations for NP_036120.1

Status: VALIDATED

Source sequence(s)

AB022345, AC101992, BB630675

Consensus CDS

CCDS17335.1

UniProtKB/Swiss-Prot

Q9WTR6

UniProtKB/TrEMBL

Q3TN05, Q542C8

Related

ENSMUSP00000029297.5, ENSMUST00000029297.6

Conserved Domains (2) summary

TIGR00911
Location:1 → 498

2A0308; L-type amino acid transporter

cl00456
Location:42 → 291

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

50319385..50403947 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500777.4 → XP_006500840.1 cystine/glutamate transporter isoform X2

Conserved Domains (1) summary

TIGR00911
Location:78 → 457

2A0308; L-type amino acid transporter
XM_017319590.3 → XP_017175079.1 cystine/glutamate transporter isoform X3

Conserved Domains (1) summary

TIGR00911
Location:1 → 322

2A0308; L-type amino acid transporter
XM_006500776.5 → XP_006500839.1 cystine/glutamate transporter isoform X1

UniProtKB/TrEMBL

Q3TN05

Conserved Domains (1) summary

TIGR00911
Location:1 → 479

2A0308; L-type amino acid transporter