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    Tapbpl TAP binding protein-like [ Mus musculus (house mouse) ]

    Gene ID: 213233, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tapbplprovided by MGI
    Official Full Name
    TAP binding protein-likeprovided by MGI
    Primary source
    MGI:MGI:2384853
    See related
    Ensembl:ENSMUSG00000038213 AllianceGenome:MGI:2384853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tapbplr; TAPBPL-R
    Summary
    Predicted to enable MHC class I protein complex binding activity and TAP complex binding activity. Predicted to be involved in negative regulation of antigen processing and presentation of peptide antigen via MHC class I and peptide antigen assembly with MHC class I protein complex. Predicted to be located in endoplasmic reticulum. Predicted to be part of MHC class I peptide loading complex. Orthologous to human TAPBPL (TAP binding protein like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 16.5), large intestine adult (RPKM 16.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tapbpl in Genome Data Viewer
    Location:
    6 F3; 6 59.32 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125200890..125208823, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125223927..125231860, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17335 Neighboring gene predicted gene, 52878 Neighboring gene STARR-positive B cell enhancer ABC_E1712 Neighboring gene vesicle-associated membrane protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:125172222-125172506 Neighboring gene RIKEN cDNA E130112N10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6490 Neighboring gene microRNA 8113 Neighboring gene CD27 antigen Neighboring gene predicted gene, 53066

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A human TAPBP (TAPASIN)-related gene, TAPBP-R. Teng MS, et al. Eur J Immunol, 2002 Apr. PMID 11920573
    2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27679

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class I protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MHC class I protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MHC class I protein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TAP complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of antigen processing and presentation of peptide antigen via MHC class I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of antigen processing and presentation of peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide antigen assembly with MHC class I protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide antigen assembly with MHC class I protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide antigen assembly with MHC class I protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MHC class I peptide loading complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tapasin-related protein
    Names
    TAP-binding protein-related protein
    TAPASIN-R
    TAPBP-R
    tapasin-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145391.2 → NP_663366.2  tapasin-related protein precursor

      See identical proteins and their annotated locations for NP_663366.2

      Status: VALIDATED

      Source sequence(s)
      AA762569, AC140324, BC094656, BX517366
      Consensus CDS
      CCDS20547.1
      UniProtKB/Swiss-Prot
      E9QN33, Q8VD31
      Related
      ENSMUSP00000047105.8, ENSMUST00000043422.8
      Conserved Domains (3) summary
      smart00410
      Location:209 → 299
      IG_like; Immunoglobulin like
      pfam07686
      Location:209 → 306
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:271 → 401
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      125200890..125208823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255302.2 → XP_030111162.1  tapasin-related protein isoform X1

      Conserved Domains (2) summary
      pfam07686
      Location:202 → 289
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:264 → 394
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VD31.2 GenPept UniProtKB/Swiss-Prot:Q8VD31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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