RAP2.12 uncharacterized protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RAP2.12
Official Full Name: uncharacterized protein
Primary source: TAIR:AT1G53910
Locus tag: AT1G53910
See related: Araport:AT1G53910
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: related to AP2 12; T18A20.14; T18A20_14
Summary: Encodes a member of the ERF (ethylene response factor) subfamily B-2 of ERF/AP2 transcription factor family (RAP2.12). The protein contains one AP2 domain. There are 5 members in this subfamily including RAP2.2 AND RAP2.12. Involved in oxygen sensing.
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Genomic context

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See RAP2.12 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (20134844..20137013)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACBP4-WRKY70-RAP2.12 module positively regulates submergence-induced hypoxia response in Arabidopsis thaliana.
Title: ACBP4-WRKY70-RAP2.12 module positively regulates submergence-induced hypoxia response in Arabidopsis thaliana.
Binding of C18:1-CoA by ACYL-COA BINDING PROTEIN 1 (ACBP1) at the plasma membrane concomitantly leads to release and nuclear accumulation of the ERFVII transcription factor RELATED TO APETALA 2.12 (RAP2.12) which is central to the activation of anaerobic metabolism during stress.
Title: The ACBP1-RAP2.12 signalling hub: A new perspective on integrative signalling during hypoxia in plants.
Ethylene-mediated NO depletion and consequent ERFVII accumulation pre-adapts plants to survive subsequent hypoxia.
Title: Ethylene-mediated nitric oxide depletion pre-adapts plants to hypoxia stress.
ERF74 and ERF75 play a redundant role in the up-regulation of RbohD transcription and enhance the ROS burst during the early stages of the stress response. [ERF74]
Title: ETHYLENE RESPONSE FACTOR 74 (ERF74) plays an essential role in controlling a respiratory burst oxidase homolog D (RbohD)-dependent mechanism in response to different stresses in Arabidopsis.
Hypoxic root bending is inhibited by the group VII ethylene response factor (ERFVII) RAP2.12, as rap2.12-1 seedlings show exaggerated primary root bending.
Title: Root Bending Is Antagonistically Affected by Hypoxia and ERF-Mediated Transcription via Auxin Signaling.
Results show that oxygen-sensing, mediating transcription factor RAP2.12 degradation is indispensable to optimize metabolic performance, plant growth, and development under both normoxic and hypoxic conditions.
Title: Oxygen Sensing via the Ethylene Response Transcription Factor RAP2.12 Affects Plant Metabolism and Performance under Both Normoxia and Hypoxia.
An evolutionarily conserved 12-bp cis-regulatory motif that binds to and is sufficient for activation by RAP2.2 and RAP2.12 is identified.
Title: Redundant ERF-VII Transcription Factors Bind to an Evolutionarily Conserved cis-Motif to Regulate Hypoxia-Responsive Gene Expression in Arabidopsis.
RAP2.2, RAP2.3 and RAP2.12 play a role in modulating oxidative and osmotic stress tolerance during submergence acclimation.
Title: The low oxygen, oxidative and osmotic stress responses synergistically act through the ethylene response factor VII genes RAP2.12, RAP2.2 and RAP2.3.
In Arabidopsis, an effective low oxygen-sensing response requires RAP2.12 stabilization followed by HRA1 induction to modulate the extent of the anaerobic response by negative feedback regulation of RAP2.12.
Title: A trihelix DNA binding protein counterbalances hypoxia-responsive transcriptional activation in Arabidopsis.
identification of a conserved amino-terminal amino acid sequence of RAP2.12 to be dedicated to an oxygen-dependent sequence of post-translational modifications, which ultimately lead to degradation of RAP2.12 under aerobic conditions
Title: Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001036108.3

Supported by ESTs:

NM_001084249.1

Supported by ESTs:

NM_104269.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within detection of hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in ethylene-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: uncharacterized protein

NP_001031185.1

related to AP2 12 (RAP2.12); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: related to AP2 2 (TAIR:AT3G14230.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_001077718.1

related to AP2 12 (RAP2.12); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: related to AP2 2 (TAIR:AT3G14230.2); Has 6180 Blast hits to 5848 proteins in 262 species: Archae - 0; Bacteria - 6; Metazoa - 0; Fungi - 0; Plants - 6130; Viruses - 0; Other Eukaryotes - 44 (source: NCBI BLink).

NP_175794.1

related to AP2 12 (RAP2.12); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: related to AP2 2 (TAIR:AT3G14230.3); Has 6179 Blast hits to 5848 proteins in 260 species: Archae - 0; Bacteria - 6; Metazoa - 0; Fungi - 0; Plants - 6129; Viruses - 0; Other Eukaryotes - 44 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

20134844..20137013

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104269.4 → NP_175794.1 uncharacterized protein AT1G53910 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_175794.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23113, Q8L9V3, Q9SSA8

UniProtKB/TrEMBL

A0A178WE84, B9DG10

Conserved Domains (1) summary

smart00380
Location:124 → 182

AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs
NM_001036108.3 → NP_001031185.1 uncharacterized protein AT1G53910 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031185.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23113, Q8L9V3, Q9SSA8

UniProtKB/TrEMBL

A0A178WE84, B9DG10

Conserved Domains (1) summary

smart00380
Location:124 → 182

AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs
NM_001084249.1 → NP_001077718.1 uncharacterized protein AT1G53910 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001077718.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WE84, A8MRC0

Conserved Domains (1) summary

smart00380
Location:122 → 180

AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs