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    MGL methionine gamma-lyase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842774, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MGL
    Official Full Name
    methionine gamma-lyase
    Primary source
    TAIR:AT1G64660
    Locus tag
    AT1G64660
    See related
    Araport:AT1G64660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMGL; F1N19.23; F1N19_23; methionine gamma-lyase
    Summary
    Encodes a functional methionine gamma-lyase, a cytosolic enzyme catalyzes the degradation of methionine into methanethiol, alpha-ketobutyrate and ammonia. The catabolism of excess methionine is important to methionine homeostasis.
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    Genomic context

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    See MGL in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (24028830..24030780)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene with no lysine (K) kinase 10 Neighboring gene early nodulin-like protein 8 Neighboring gene Major facilitator superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene beta-carotene isomerase D27 Neighboring gene branchless trichome

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway. Goyer A, et al. Plant Cell Physiol, 2007 Feb. PMID 17169919
    2. Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses. Rébeillé F, et al. Proc Natl Acad Sci U S A, 2006 Oct 17. PMID 17030798, Free PMC Article
    3. Arabidopsis methionine gamma-lyase is regulated according to isoleucine biosynthesis needs but plays a subordinate role to threonine deaminase. Joshi V, et al. Plant Physiol, 2009 Sep. PMID 19571310, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MGL makes a significant contribution to methionine degradation, particularly in reproductive tissue, suggests practical applications for silencing the expression of MGL in crop plants.
      Title: Arabidopsis methionine gamma-lyase is regulated according to isoleucine biosynthesis needs but plays a subordinate role to threonine deaminase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_105141.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables methionine gamma-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to sulfate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within methionine catabolic process via 2-oxobutanoate TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transsulfuration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine gamma-lyase
    NP_176647.1
    • methionine gamma-lyase (MGL); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (InterPro:IPR000277), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT3G01120.1); Has 19547 Blast hits to 19544 proteins in 2474 species: Archae - 216; Bacteria - 11847; Metazoa - 211; Fungi - 771; Plants - 270; Viruses - 0; Other Eukaryotes - 6232 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24028830..24030780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105141.3 → NP_176647.1  methionine gamma-lyase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176647.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SGU9
      UniProtKB/TrEMBL
      A0A7G2E4V1
      Conserved Domains (1) summary
      PLN02242
      Location:26 → 441
      PLN02242; methionine gamma-lyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SGU9.1

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