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    ACA1 autoinhibited Ca2+-ATPase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839670, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACA1
    Official Full Name
    autoinhibited Ca2+-ATPase 1
    Primary source
    TAIR:AT1G27770
    Locus tag
    AT1G27770
    See related
    Araport:AT1G27770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    autoinhibited Ca2+-ATPase 1; CA2+-ATPASE; PEA1; PLASTID ENVELOPE ATPASE 1; T22C5.23; T22C5_23
    Summary
    Encodes a chloroplast envelope Ca2+-ATPase with an N-terminal autoinhibitor.
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    Genomic context

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    See ACA1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (9671632..9676307, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene nucleic acid binding protein Neighboring gene Ubiquitin system component Cue protein Neighboring gene interferon-related developmental regulator family protein / IFRD protein family Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a gene encoding a Ca(2+)-ATPase-like protein in the plastid envelope. Huang L, et al. Proc Natl Acad Sci U S A, 1993 Nov 1. PMID 8234257, Free PMC Article
    2. A calmodulin-stimulated Ca2+-ATPase from plant vacuolar membranes with a putative regulatory domain at its N-terminus. Malmström S, et al. FEBS Lett, 1997 Jan 6. PMID 9009223
    3. Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice. Baxter I, et al. Plant Physiol, 2003 Jun. PMID 12805592, Free PMC Article
    4. Genes encoding calmodulin-binding proteins in the Arabidopsis genome. Reddy VS, et al. J Biol Chem, 2002 Mar 22. PMID 11782485
    5. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_102542.1
    NM_179385.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables P-type calcium transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calcium channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast inner membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    autoinhibited Ca2+-ATPase 1
    NP_564295.1
    • autoinhibited Ca2+-ATPase 1 (ACA1); FUNCTIONS IN: calcium channel activity, calcium-transporting ATPase activity, calmodulin binding; INVOLVED IN: cation transport, calcium ion transport, ATP biosynthetic process; LOCATED IN: endoplasmic reticulum, plasma membrane, chloroplast inner membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, calcium-transporting, PMCA-type (InterPro:IPR006408), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), ATPase, P-type cation exchange, alpha subunit (InterPro:IPR006069), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303), ATPase, P-type cation-transporter, C-terminal (InterPro:IPR006068); BEST Arabidopsis thaliana protein match is: calcium ATPase 2 (TAIR:AT4G37640.1); Has 48793 Blast hits to 33205 proteins in 3149 species: Archae - 856; Bacteria - 30326; Metazoa - 5666; Fungi - 3781; Plants - 2732; Viruses - 4; Other Eukaryotes - 5428 (source: NCBI BLink).
    NP_849716.1
    • autoinhibited Ca2+-ATPase 1 (ACA1); FUNCTIONS IN: calcium channel activity, calcium-transporting ATPase activity, calmodulin binding; INVOLVED IN: cation transport, calcium ion transport, metabolic process, ATP biosynthetic process; LOCATED IN: endoplasmic reticulum, plasma membrane, chloroplast inner membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, calcium-transporting, PMCA-type (InterPro:IPR006408), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type cation-transporter, C-terminal (InterPro:IPR006068), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: calcium ATPase 2 (TAIR:AT4G37640.1); Has 48177 Blast hits to 34612 proteins in 3273 species: Archae - 915; Bacteria - 33514; Metazoa - 4128; Fungi - 2798; Plants - 2164; Viruses - 3; Other Eukaryotes - 4655 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      9671632..9676307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332786.1 → NP_001321521.1  autoinhibited Ca2+-ATPase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AR51

    2. NM_001332787.1 → NP_001321522.1  autoinhibited Ca2+-ATPase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q37145, Q37146, Q42571, Q42587, Q9SFY1
      UniProtKB/TrEMBL
      A0A178WD16, A0A5S9W3P6
      Conserved Domains (2) summary
      TIGR01517
      Location:59 → 1017
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12515
      Location:5 → 50
      CaATP_NAI; Ca2+-ATPase N terminal autoinhibitory domain

    3. NM_179385.2 → NP_849716.1  autoinhibited Ca2+-ATPase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849716.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q37145, Q37146, Q42571, Q42587, Q9SFY1
      UniProtKB/TrEMBL
      A0A178WD16, A0A5S9W3P6
      Conserved Domains (2) summary
      TIGR01517
      Location:59 → 1017
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12515
      Location:5 → 50
      CaATP_NAI; Ca2+-ATPase N terminal autoinhibitory domain

    4. NM_102542.1 → NP_564295.1  autoinhibited Ca2+-ATPase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4HUS8
      Conserved Domains (7) summary
      COG4087
      Location:639 → 719
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01517
      Location:59 → 943
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:206 → 445
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:768 → 941
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:118 → 186
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12515
      Location:5 → 50
      CaATP_NAI; Ca2+-ATPase N terminal autoinhibitory domain
      pfam13246
      Location:512 → 594
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q37145.3

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