ANNAT1 annexin 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ANNAT1
Official Full Name: annexin 1
Primary source: TAIR:AT1G35720
Locus tag: AT1G35720
See related: Araport:AT1G35720
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ANN1; ANNEXIN; annexin 1; ANNEXIN A1; AtANN1; ATOXY5; F14D7.2; F14D7_2; OXY5
Summary: Encodes a member of the annexin gene family, a diverse, multigene family of calcium-dependent, membrane-binding proteins. The protein was determined to have peroxidase activity. This activity is thought to be dependent on the presence of post-translational modifications (most likely phosphorylation). The protein was shown to be present as a mixture of monomer and homodimer. The homodimerization seems to be dependent on the presence of Ca2+ or H2O2. The dimerization was prevented by the addition of DTT, beta-mercaptoethanol and TCEP. Annat1 mRNA is expressed in flowers, roots,leaves and stems and is most abundant in stems. mRNA levels are increased in response to oxidative stress. Developmental expression patterns suggest a role in Golgi-mediated polysaccharide secretion. It is a Ca 2+-permeable transporter providing a molecular link between reactive oxygen species and cytosolic Ca 2+ in plants.
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Genomic context

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See ANNAT1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (13225168..13227239)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Annexin 1 Is a Component of eATP-Induced Cytosolic Calcium Elevation in Arabidopsis thaliana Roots.
Title: Annexin 1 Is a Component of eATP-Induced Cytosolic Calcium Elevation in Arabidopsis thaliana Roots.
Results indicate that annexins ANN1 and ANN2 play an important role in post-phloem sugar transport to the root tip, which in turn indirectly influences photosynthetic rates in cotyledons.
Title: ANN1 and ANN2 Function in Post-Phloem Sugar Transport in Root Tips to Affect Primary Root Growth.
MYB30 regulates oxidative and heat stress responses through calcium signaling, which is at least partially mediated by ANN1 and ANN4.
Title: MYB30 transcription factor regulates oxidative and heat stress responses through ANNEXIN-mediated cytosolic calcium signaling in Arabidopsis.
Study indicated that CERK1 physically interacts with ANNEXIN 1 (ANN1), which was reported to form a calcium-permeable channel that contributes to the NaCl-induced [Ca(2+) ]cyt signal. In turn, ann1 mutants showed elevated chitin-induced rapid responses
Title: Chitin receptor CERK1 links salt stress and chitin-triggered innate immunity in Arabidopsis.
Results suggest that AtANN1 is important in regulating the heat-induced increase in [Ca(2+)]cytoplasmic and in the response of Arabidopsis seedlings to heat stress.
Title: Proteomic study of microsomal proteins reveals a key role for Arabidopsis annexin 1 in mediating heat stress-induced increase in intracellular calcium levels.
AtANN1 is involved in shaping the root peroxide-induced cytosolic free Ca(2+) ([Ca(2+) ]cyt ) signature and downstream signalling.
Title: Annexin 1 regulates the H2O2-induced calcium signature in Arabidopsis thaliana roots.
AtANN1 as a key component of root cell adaptation to salinity. [AtANN1]
Title: Salinity-induced calcium signaling and root adaptation in Arabidopsis require the calcium regulatory protein annexin1.
The Arabidopsis loss-of-function mutant for annexin1 (Atann1) was found to lack the root hair and epidermal hydroxyl radical-activated Ca(2)+ - and K+ -permeable conductance.[Annexin1]
Title: Arabidopsis annexin1 mediates the radical-activated plasma membrane Ca²+- and K+-permeable conductance in root cells.
AnnAt1 and AnnAt4 interact with each other in a Ca2+-dependent manner and function to regulate responses to drought and salt stress.
Title: Arabidopsis annexins AnnAt1 and AnnAt4 interact with each other and regulate drought and salt stress responses.
AnnAt1 has a role in oxidative protection.
Title: The role of annexin 1 in drought stress in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_103274.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	HDA more info	PubMed
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables copper ion binding	HDA more info	PubMed
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	HDA more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phloem sucrose unloading	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within primary root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plant-type cell wall	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in root hair tip	IDA Inferred from Direct Assay more info	PubMed
located_in thylakoid	HDA more info	PubMed

General protein information

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Preferred Names: annexin 1

NP_174810.1

annexin 1 (ANNAT1); FUNCTIONS IN: in 7 functions; INVOLVED IN: in 8 processes; LOCATED IN: in 10 components; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Annexin like protein (InterPro:IPR015472), Annexin repeat (InterPro:IPR018502), Annexin repeat, conserved site (InterPro:IPR018252), Annexin (InterPro:IPR001464), Annexin, type plant (InterPro:IPR009118); BEST Arabidopsis thaliana protein match is: annexin 2 (TAIR:AT5G65020.1); Has 3809 Blast hits to 2217 proteins in 205 species: Archae - 0; Bacteria - 0; Metazoa - 2893; Fungi - 160; Plants - 482; Viruses - 0; Other Eukaryotes - 274 (source: NCBI BLink).