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    HAL3A HAL3-like protein A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821327, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HAL3A
    Official Full Name
    HAL3-like protein A
    Primary source
    TAIR:AT3G18030
    Locus tag
    AT3G18030
    See related
    Araport:AT3G18030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA HAL3-LIKE PROTEIN A; ATHAL3; ATHAL3A; HAL3; HAL3-like protein A; HALOTOLERANCE DETERMINANT 3
    Summary
    flavin mononucleotide flavoprotein involved in salt and osmotic tolerance HAL3A encodes for phosphopantothenoylcysteine decarboxylase being involved in Coenzyme A biosynthesis. HAL3A is predominant over another gene with the presumably same function (HAL3B).
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    Genomic context

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    See HAL3A in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (6167640..6168966, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene WUSCHEL related homeobox 1 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene winged-helix DNA-binding transcription factor family protein Neighboring gene MAP kinase 9 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment. Rubio S, et al. Plant Physiol, 2006 Mar. PMID 16415216, Free PMC Article
    2. The X-ray structure of the FMN-binding protein AtHal3 provides the structural basis for the activity of a regulatory subunit involved in signal transduction. Albert A, et al. Structure, 2000 Sep 15. PMID 10986463
    3. Arabidopsis thaliana AtHAL3: a flavoprotein related to salt and osmotic tolerance and plant growth. Espinosa-Ruiz A, et al. Plant J, 1999 Dec. PMID 10652125
    4. 4'-phosphopantetheine and coenzyme A biosynthesis in plants. Kupke T, et al. J Biol Chem, 2003 Oct 3. PMID 12860978
    5. Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function. Santolaria C, et al. Sci Rep, 2018 Oct 2. PMID 30279472, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Site-directed mutagenesis results indicate that in AtHal3 residues G115 and L117 are not relevant for trimerization, and their mutation do not affect phosphopantothenoyl-cysteine decarboxylase function.
      Title: Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function.
    2. HAL3A is involved in coenzyme A biosynthesis and are therefore critical to early postgerminative growth.
      Title: An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112684.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables FMN binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphopantothenoylcysteine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphopantothenoylcysteine decarboxylase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within coenzyme A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in coenzyme A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within coenzyme A biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic salinity response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    HAL3-like protein A
    NP_188430.1
    • HAL3-like protein A (HAL3A); CONTAINS InterPro DOMAIN/s: Flavoprotein (InterPro:IPR003382); BEST Arabidopsis thaliana protein match is: Flavoprotein (TAIR:AT1G48605.1); Has 7047 Blast hits to 7045 proteins in 2495 species: Archae - 186; Bacteria - 4343; Metazoa - 125; Fungi - 269; Plants - 90; Viruses - 5; Other Eukaryotes - 2029 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6167640..6168966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112684.5 → NP_188430.1  HAL3-like protein A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188430.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6ID92, Q9SWE5
      UniProtKB/TrEMBL
      A0A178VKW1, A0A5S9XD75, A0A654FA54, A0A7G2ER38
      Conserved Domains (1) summary
      PLN02496
      Location:7 → 209
      PLN02496; probable phosphopantothenoylcysteine decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SWE5.1

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