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    TMK1 transmembrane kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842930, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TMK1
    Official Full Name
    transmembrane kinase 1
    Primary source
    TAIR:AT1G66150
    Locus tag
    AT1G66150
    See related
    Araport:AT1G66150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F15E12.4; F15E12_4; transmembrane kinase 1
    Summary
    receptor-like transmembrane kinase I (TMK1)
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    Genomic context

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    See TMK1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (24631338..24634781)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene zinc finger protein 4 Neighboring gene CLAVATA3/ESR-RELATED 18 Neighboring gene CYS, MET, PRO, and GLY protein 1 Neighboring gene RING/FYVE/PHD zinc finger superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The TMK1 gene from Arabidopsis codes for a protein with structural and biochemical characteristics of a receptor protein kinase. Chang C, et al. Plant Cell, 1992 Oct. PMID 1332795, Free PMC Article
    2. Receptor-like kinase activity in membranes of Arabidopsis thaliana. Schaller GE, et al. FEBS Lett, 1993 Nov 1. PMID 8224199
    3. TMK: A crucial piece of the acid growth puzzle. Peng Y, et al. Mol Plant, 2021 Dec 6. PMID 34813950
    4. TMK1-mediated auxin signalling regulates differential growth of the apical hook. Cao M, et al. Nature, 2019 Apr. PMID 30944466
    5. External Mechanical Cues Reveal a Katanin-Independent Mechanism behind Auxin-Mediated Tissue Bending in Plants. Baral A, et al. Dev Cell, 2021 Jan 11. PMID 33434527

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Modulation of receptor-like transmembrane kinase 1 nuclear localization by DA1 peptidases in Arabidopsis.
      Title: Modulation of receptor-like transmembrane kinase 1 nuclear localization by DA1 peptidases in Arabidopsis.
    2. ABP1-TMK auxin perception for global phosphorylation and auxin canalization.
      Title: ABP1-TMK auxin perception for global phosphorylation and auxin canalization.
    3. TMK: A crucial piece of the acid growth puzzle.
      Title: TMK: A crucial piece of the acid growth puzzle.
    4. TMK-based cell-surface auxin signalling activates cell-wall acidification.
      Title: TMK-based cell-surface auxin signalling activates cell-wall acidification.
    5. TMK1-based auxin signaling regulates abscisic acid responses via phosphorylating ABI1/2 in Arabidopsis.
      Title: TMK1-based auxin signaling regulates abscisic acid responses via phosphorylating ABI1/2 in Arabidopsis.
    6. Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism.
      Title: Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism.
    7. External Mechanical Cues Reveal a Katanin-Independent Mechanism behind Auxin-Mediated Tissue Bending in Plants.
      Title: External Mechanical Cues Reveal a Katanin-Independent Mechanism behind Auxin-Mediated Tissue Bending in Plants.
    8. TMK1-mediated auxin signalling regulates differential growth of the apical hook
      Title: TMK1-mediated auxin signalling regulates differential growth of the apical hook.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105286.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane receptor protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of auxin mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    transmembrane kinase 1
    NP_176789.1
    • transmembrane kinase 1 (TMK1); FUNCTIONS IN: transmembrane receptor protein serine/threonine kinase activity; INVOLVED IN: signal transduction; LOCATED IN: extracellular region, plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat, typical subtype (InterPro:IPR003591), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT2G01820.1); Has 173049 Blast hits to 137802 proteins in 4904 species: Archae - 168; Bacteria - 18898; Metazoa - 54853; Fungi - 11361; Plants - 66018; Viruses - 436; Other Eukaryotes - 21315 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24631338..24634781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105286.4 → NP_176789.1  transmembrane kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176789.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LGH9, P43298, Q84R13
      UniProtKB/TrEMBL
      A0A178WEY8, A0A5S9WSJ3, A0A654ERJ7
      Conserved Domains (3) summary
      PLN00113
      Location:28 → 867
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      cd14066
      Location:594 → 868
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      sd00033
      Location:90 → 112
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43298.1

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