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    Peptidase M50 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827778, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Peptidase M50 family protein
    Primary source
    TAIR:AT4G20310
    Locus tag
    AT4G20310
    See related
    Araport:AT4G20310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F1C12.220; F1C12_220
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (10961556..10964089)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 11 Neighboring gene Serine/Threonine-kinase, putative (DUF1639) Neighboring gene CTP synthase family protein Neighboring gene ribonuclease H2 subunit B Neighboring gene Transcription initiation factor TFIIE, beta subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Signaling from the endoplasmic reticulum activates brassinosteroid signaling and promotes acclimation to stress in Arabidopsis. Che P, et al. Sci Signal, 2010 Sep 28. PMID 20876872
    2. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001160784.2
    NM_001341411.1
    NM_001341412.1
    NM_001341413.1
    NM_001341414.1
    NM_001341415.1
    NM_001341416.1
    NM_001341417.1
    NM_001341418.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of brassinosteroid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase M50 family protein
    NP_001154256.1
    • Peptidase M50 family protein; FUNCTIONS IN: metalloendopeptidase activity; INVOLVED IN: proteolysis; LOCATED IN: membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M50, mammalian sterol-regulatory element binding protein (InterPro:IPR001193), Peptidase M50 (InterPro:IPR008915); Has 359 Blast hits to 357 proteins in 139 species: Archae - 138; Bacteria - 13; Metazoa - 104; Fungi - 6; Plants - 70; Viruses - 0; Other Eukaryotes - 28 (source: NCBI BLink).
    NP_001320006.1
    • Peptidase M50 family protein; FUNCTIONS IN: metalloendopeptidase activity; INVOLVED IN: proteolysis; LOCATED IN: membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M50, mammalian sterol-regulatory element binding protein (InterPro:IPR001193), Peptidase M50 (InterPro:IPR008915); Has 349 Blast hits to 349 proteins in 137 species: Archae - 138; Bacteria - 13; Metazoa - 102; Fungi - 6; Plants - 62; Viruses - 0; Other Eukaryotes - 28 (source: NCBI BLink).
    NP_001320007.1
    • Peptidase M50 family protein; FUNCTIONS IN: metalloendopeptidase activity; INVOLVED IN: proteolysis; LOCATED IN: endomembrane system; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M50 (InterPro:IPR008915); Has 156 Blast hits to 154 proteins in 70 species: Archae - 19; Bacteria - 0; Metazoa - 104; Fungi - 2; Plants - 26; Viruses - 0; Other Eukaryotes - 5 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10961556..10964089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341412.1 → NP_001320007.1  Peptidase M50 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178USU7, A0A384L4B3, F4JUU7

    2. NM_001160784.2 → NP_001154256.1  Peptidase M50 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154256.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178USU7, A0A384L4B3, F4JUU7
      Conserved Domains (1) summary
      pfam02163
      Location:3 → 113
      Peptidase_M50; Peptidase family M50

    3. NM_001341413.1 → NP_001328927.1  Peptidase M50 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JUU5, O65444
      UniProtKB/TrEMBL
      A0A0F6SCX9, A0A654FR44
      Conserved Domains (1) summary
      cl10020
      Location:42 → 196
      S2P-M50; Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic ...

    4. NM_001341415.1 → NP_001328925.1  Peptidase M50 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B655

    5. NM_001341414.1 → NP_001328926.1  Peptidase M50 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B657, A0A654FR44

    6. NM_001341416.1 → NP_001328924.1  Peptidase M50 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178USU7, A0A384L4B3, F4JUU7

    7. NM_001341417.1 → NP_001328929.1  Peptidase M50 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B660
      Conserved Domains (1) summary
      cl10020
      Location:42 → 196
      S2P-M50; Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic ...

    8. NM_001341418.1 → NP_001328928.1  Peptidase M50 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178USU7, A0A384L4B3, F4JUU7

    9. NM_001341411.1 → NP_001320006.1  Peptidase M50 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JUU6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JUU5.2

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